Document Detail


Rapeseed protein inhibits the initiation of insulin resistance by a high-saturated fat, high-sucrose diet in rats.
MedLine Citation:
PMID:  18394216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In contrast to the quality of carbohydrates and lipids, little is known on the influence of the type of dietary protein on the development of the metabolic or insulin resistance syndrome. Cysteine intake has been recently documented to impact insulin sensitivity. The aim of this study was to determine whether rapeseed protein, an emergent cysteine-rich protein, could inhibit the onset of the metabolic syndrome. For 9 weeks, rats were fed a diet rich in saturated fats and sucrose, which also included 20 % protein either as milk protein ('Induction' diet I) or rapeseed protein (diet R). A third, control group received an isoenergetic diet containing milk protein but polyunsaturated fats and starch ('Prudent' diet P). Plasma glucose, insulin, TAG and cholesterol, and blood pressure were monitored during the study, glucose tolerance was tested at week 7 and body composition determined at week 9. Plasma glucose, insulin and TAG increased during the experiment and, at week 9, plasma insulin was significantly 34 % lower in the R group and 56 % lower in P group as compared with the I group. The insulin peak after the glucose load was significantly 28-30 % lower in R and P than in I and the insulin sensitivity index was significantly higher in R than in I. Unexpectedly, peripheral fat deposition was slightly higher in R than in I. In this model, substituting rapeseed protein for milk protein had preventive effects on the early onset of insulin resistance, similar to those achieved by manipulating the types of dietary fat and carbohydrates.
Authors:
François Mariotti; Dominique Hermier; Charlotte Sarrat; Joëlle Magné; Evelyne Fénart; Jacques Evrard; Daniel Tomé; Jean François Huneau
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-08
Journal Detail:
Title:  The British journal of nutrition     Volume:  100     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2008-11-18     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  984-91     Citation Subset:  IM    
Affiliation:
AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France. francois.mariotti@agroparistech.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood
Blood Glucose / analysis
Brassica rapa*
Dietary Carbohydrates / adverse effects*
Dietary Fats / adverse effects*
Dietary Proteins / administration & dosage*
Fatty Acids, Omega-3 / administration & dosage
Glucose Tolerance Test
Glutathione / blood
Insulin / blood
Insulin Resistance*
Male
Milk Proteins / administration & dosage
Models, Animal
Plant Proteins / administration & dosage
Rats
Rats, Wistar
Sucrose / adverse effects*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Fatty Acids, Omega-3; 0/Milk Proteins; 0/Plant Proteins; 0/Triglycerides; 11061-68-0/Insulin; 57-50-1/Sucrose; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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