Document Detail


Rapeseed induced liver haemorrhage, reticulolysis and biochemical changes in laying hens: the effects of feeding high and low glucosinolate meals.
MedLine Citation:
PMID:  6463374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rapeseed meal hepatosis was produced by feeding high and low glucosinolate meals as a source of protein (about 200 g kg-1 diet) but could not be distinguished histologically from fatty liver-haemorrhagic syndrome which occurred in birds on the control diet. Both types of meal increased haemorrhage, reticulolysis and lymphoproliferation in the liver, reduced the packed cell volume and caused thyroid enlargement. Haemorrhages emanated from ruptured intrahepatic portal veins, capillaries and sinusoids and were associated with degenerative changes in vessel walls. Haemorrhage and reticulin scores were correlated. Parenchymal necrosis occurred only around large haematomas and caused increased aspartate transaminase activity in the plasma. Both meals also caused hyperglycaemia and reduced the plasma triglyceride content. Only the high glucosinolate meal decreased egg production, caused liver enlargement and reduced the plasma urate level. The addition of myrosinase enhanced its effects on egg production and packed cell volume but did not increase its hepatotoxicity.
Authors:
M F Martland; E J Butler; G R Fenwick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  36     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-09-06     Completed Date:  1984-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  298-309     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brassica*
Chickens*
Female
Glucosinolates / administration & dosage,  poisoning*
Glycoside Hydrolases / administration & dosage
Hemorrhage / blood,  pathology,  veterinary*
Liver / pathology
Liver Diseases / blood,  pathology,  veterinary*
Plant Poisoning / blood,  pathology,  veterinary*
Poultry Diseases / pathology*
Reticulin / metabolism
Thioglycosides / poisoning*
Chemical
Reg. No./Substance:
0/Glucosinolates; 0/Reticulin; 0/Thioglycosides; EC 3.2.1.-/Glycoside Hydrolases; EC 3.2.1.147/thioglucosidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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