| Rapamycin inhibits activator protein-1 but not nuclear factor-kappaB activity of mature bone marrow-derived dendritic cells. | |
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MedLine Citation:
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PMID: 20620542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rapamycin (Rapa), a recently introduced immunosuppressive drug, appears to be effective in preventing acute allograft rejection episodes. Its effects on differentiation and maturation of dendritic cells (DCs) have been studied. In this report, we evaluated the effects of Rapa on the intracellular signal transduction pathways in mature DCs. The results showed that Rapa did not depress p65, p50, or IkappaBalpha expression. However, it dramatically reduced activator protein-1 activation. The fact that Rapa exerts a specific effect on activator protein-1 activity in mature DCs may contribute to its unique actions to prevent allograft rejection and induce immune tolerance. |
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Authors:
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G-Y Wang; G-H Chen; H Li; Y Huang; J Zhang; N Jiang; W-J Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 1881-3 Citation Subset: IM |
Affiliation:
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Liver Transplantation Institution, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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genetics Animals Bone Marrow Cells / cytology*, drug effects Cell Nucleus / drug effects, physiology Dendritic Cells / cytology, drug effects, physiology* NF-kappa B / drug effects, genetics, physiology* Rats Rats, Inbred Lew Reverse Transcriptase Polymerase Chain Reaction Sirolimus / pharmacology* Transcription Factor AP-1 / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/NF-kappa B; 0/Transcription Factor AP-1; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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