Document Detail

Ranitidine is unable to maintain gastric pH levels above 4 in septic patients.
MedLine Citation:
PMID:  19931156     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The study aimed to evaluate whether ranitidine and pantoprazole are able to maintain gastric pH >or=4 in septic patients.
MATERIALS AND METHODS: Twenty intensive care unit patients from a university teaching hospital with sepsis were included in this study. Ten patients received ranitidine (50 mg as an intermittent bolus 3 times a day) and 10 received pantoprazole (40 mg as an intermittent bolus twice a day). Gastric pH was measured continuously for 48 hours. Endoscopy of the upper digestive tract, gastric biopsy, and investigation for Helicobacter pylori were carried out before and at the end of the study.
RESULTS: pH values >or=4 were maintained for 46.27% +/- 38.21% and 81.57% +/- 19.65% of study time in the ranitidine and pantoprazole groups, respectively (P = .04).
CONCLUSIONS: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4.
Cristina B Terzi Coelho; Desanka Dragosavac; João S Coelho Neto; Ciro G Montes; Fábio Guerrazzi; Nelson Adami Andreollo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of critical care     Volume:  24     ISSN:  1557-8615     ISO Abbreviation:  J Crit Care     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-03-04     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627.e7-13     Citation Subset:  IM    
Intensive Care Unit, Teaching Hospital of the State University of Campinas, Campinas, São Paulo, Brazil.
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MeSH Terms
2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use*
Anti-Ulcer Agents / therapeutic use*
Gastric Acid / chemistry
Histamine H2 Antagonists / therapeutic use*
Hydrogen-Ion Concentration
Middle Aged
Ranitidine / therapeutic use*
Sepsis / drug therapy*
Time Factors
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Histamine H2 Antagonists; 66357-35-5/Ranitidine; D8TST4O562/pantoprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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