| Ranitidine is unable to maintain gastric pH levels above 4 in septic patients. | |
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MedLine Citation:
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PMID: 19931156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The study aimed to evaluate whether ranitidine and pantoprazole are able to maintain gastric pH >or=4 in septic patients. MATERIALS AND METHODS: Twenty intensive care unit patients from a university teaching hospital with sepsis were included in this study. Ten patients received ranitidine (50 mg as an intermittent bolus 3 times a day) and 10 received pantoprazole (40 mg as an intermittent bolus twice a day). Gastric pH was measured continuously for 48 hours. Endoscopy of the upper digestive tract, gastric biopsy, and investigation for Helicobacter pylori were carried out before and at the end of the study. RESULTS: pH values >or=4 were maintained for 46.27% +/- 38.21% and 81.57% +/- 19.65% of study time in the ranitidine and pantoprazole groups, respectively (P = .04). CONCLUSIONS: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4. |
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Authors:
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Cristina B Terzi Coelho; Desanka Dragosavac; João S Coelho Neto; Ciro G Montes; Fábio Guerrazzi; Nelson Adami Andreollo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of critical care Volume: 24 ISSN: 1557-8615 ISO Abbreviation: J Crit Care Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-03-04 Revised Date: 2013-06-04 |
Medline Journal Info:
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Nlm Unique ID: 8610642 Medline TA: J Crit Care Country: United States |
Other Details:
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Languages: eng Pagination: 627.e7-13 Citation Subset: IM |
Affiliation:
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Intensive Care Unit, Teaching Hospital of the State University of Campinas, Campinas, São Paulo, Brazil. cristerzi@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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therapeutic use* APACHE Adult Anti-Ulcer Agents / therapeutic use* Female Gastric Acid / chemistry Histamine H2 Antagonists / therapeutic use* Humans Hydrogen-Ion Concentration Male Middle Aged Ranitidine / therapeutic use* Sepsis / drug therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Histamine H2 Antagonists; 66357-35-5/Ranitidine; D8TST4O562/pantoprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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