Document Detail

Ranitidine and somatostatin. Their effects on bleeding from the upper gastrointestinal tract.
MedLine Citation:
PMID:  2872874     Owner:  NLM     Status:  MEDLINE    
In a randomized, double-blind placebo-controlled clinical trial, the effect of ranitidine was compared with the effect of somatostatin in the control of massive gastrointestinal tract bleeding. Ninety-six patients completed the study. Rates of continuing bleeding and death, incidence of surgery, and blood transfusion requirements were not significantly different in the three treatment groups. Eighteen of the 96 patients presented with a visible vessel at endoscopy. In this group the percent of patients with continuing bleeding, mean transfusion requirements, and mortality were significantly higher than in patients without a visible vessel. Seven patients with a visible vessel underwent surgery and six survived; 11 patients underwent conservative measures and eight died. Ranitidine and somatostatin do not seem to alter the clinical course of patients with upper gastrointestinal tract hemorrhage.
N Basso; M Bagarani; F Bracci; G Cucchiara; D Gizzonio; G Grassini; M Percoco; F Procacciante; F Toti
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  121     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-07-16     Completed Date:  1986-07-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  833-5     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Transfusion
Clinical Trials as Topic
Double-Blind Method
Gastrointestinal Hemorrhage / drug therapy*,  surgery,  therapy
Infusions, Parenteral
Middle Aged
Random Allocation
Ranitidine / administration & dosage,  therapeutic use*
Somatostatin / administration & dosage,  therapeutic use*
Reg. No./Substance:
51110-01-1/Somatostatin; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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