Document Detail

Ranitidine and late-onset sepsis in the neonatal intensive care unit.
MedLine Citation:
PMID:  17302510     Owner:  NLM     Status:  MEDLINE    
AIMS: The objective of the study was to examine the effect of ranitidine on the incidence of late onset sepsis. METHODS: This study was based on information extracted from charts of 569 infants admitted to the neonatal intensive care unit (NICU) from July 2003 to July 2005. All infants admitted for seven or more days were included. Late-onset neonatal sepsis was defined as a positive blood culture with clinical signs of sepsis after seven days of life. Outcome measures included the use of ranitidine, type of infection and infectious agent, birth weight gestational age, and type of care in the NICU. RESULTS: Of the 569 infants admitted, 53 (9.3%) were treated with ranitidine. Of 74 infants who developed late-onset sepsis, 23 infants received ranitidine and 51 did not. Infants receiving ranitidine were at 7-times greater risk of late-onset sepsis (OR 6.99; 95% CI: 3.78-12.94; P<0.0001). The birth weights and gestational ages of infants with sepsis receiving ranitidine and those not receiving ranitidine were comparable, P=0.59. CONCLUSION: The use of ranitidine in infants admitted to the NICU elevates the risk of late-onset sepsis. The pathological mechanisms need to be further studied. The safety of widespread use of ranitidine in neonates is controversial.
Simona Bianconi; Madhu Gudavalli; Vesna G Sutija; Anna L Lopez; Lillian Barillas-Arias; Nitin Ron
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  35     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-08     Completed Date:  2007-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
Department of Pediatrics, New York Methodist Hospital, Brooklyn, NY 11215, USA.
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MeSH Terms
Anti-Ulcer Agents / adverse effects*
Infant, Newborn
Ranitidine / adverse effects*
Retrospective Studies
Risk Factors
Sepsis / etiology*
Reg. No./Substance:
0/Anti-Ulcer Agents; 66357-35-5/Ranitidine

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