Document Detail

Ranitidine in the treatment of gastric ulceration.
MedLine Citation:
PMID:  6277019     Owner:  NLM     Status:  MEDLINE    
Seventy-two patients with endoscopically proven gastric ulcers were entered into a prospective controlled trial to assess the efficacy of ranitidine and cimetidine in ulcer healing. All patients were biopsied on entry and at subsequent endoscopies. After exclusion of 7 patients during the first month of treatment, the remaining 65 patients, 47 males and 18 females, mean age 48.2 +/-1.5 years, at 1 month had a healing rate of 47% and 52% respectively. The non-healers continued their treatment for a further 4 weeks. This increased the healing rate to 77% and 76% respectively. If the defaulters and poor compliers are withdrawn the healing rate rises to 58% and 57% at 4 weeks and to 91% and 79% at 8 weeks respectively. There was no significant difference between the two groups as regarded initial ulcer size and severity of dyspepsia. Antacid tablet consumption during the study was comparable. The initial size of the ulcers which failed to heal after 4 weeks of treatment tended to be larger than those which healed (P less than 0.05), but smoking did not appear to influence ulcer healing. No obvious side-effects or evidence of dysplasia were found. The study shows that ranitidine is at least as effective as cimetidine in gastric ulcer healing.
J P Wright; I N Marks; A S Mee; A H Girdwood; P C Bornman; N H Gilinsky; P Tobias; W Lucke
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  61     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking
Antacids / administration & dosage
Anti-Ulcer Agents / therapeutic use*
Aspirin / administration & dosage
Cimetidine / therapeutic use
Clinical Trials as Topic
Furans / therapeutic use*
Middle Aged
Random Allocation
Stomach Ulcer / drug therapy*
Time Factors
Reg. No./Substance:
0/Antacids; 0/Anti-Ulcer Agents; 0/Furans; 80061L1WGD/Cimetidine; 884KT10YB7/Ranitidine; R16CO5Y76E/Aspirin

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