Document Detail


Ranitidine in the treatment of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drugs.
MedLine Citation:
PMID:  8508283     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effect of 4 weeks' therapy with ranitidine 150 mg twice daily on the healing of symptomatic NSAID-associated gastric and duodenal ulcers, 149 arthritic patients were randomly allocated to one of three treatment groups: ranitidine with NSAID continued, ranitidine with NSAID discontinued, and placebo with NSAID discontinued. The healing frequency in patients with gastric ulceration was 67, 68 and 47%, and in those with duodenal ulceration 61, 81 and 42%, respectively. Only the difference between the duodenal ulcer healing rates for ranitidine with NSAID discontinued and placebo was statistically significant (P = 0.02). Healing rates were uninfluenced by gender, age, smoking habits, alcohol consumption, ulcer frequency or size, arthritic disease, or participating country.
Authors:
G Tildesley; R S Ehsanullah; J R Wood
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of rheumatology     Volume:  32     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-13     Completed Date:  1993-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  474-8     Citation Subset:  AIM; IM    
Affiliation:
Hartlepool General Hospital, Cleveland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  therapeutic use
Arthritis / drug therapy*
Double-Blind Method
Drug Administration Schedule
Duodenal Ulcer / complications,  drug therapy*,  etiology
Female
Humans
Male
Middle Aged
Prospective Studies
Ranitidine / administration & dosage*,  adverse effects
Stomach Ulcer / complications,  drug therapy*,  etiology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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