| Ranitidine in the treatment of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drugs. | |
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MedLine Citation:
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PMID: 8508283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the effect of 4 weeks' therapy with ranitidine 150 mg twice daily on the healing of symptomatic NSAID-associated gastric and duodenal ulcers, 149 arthritic patients were randomly allocated to one of three treatment groups: ranitidine with NSAID continued, ranitidine with NSAID discontinued, and placebo with NSAID discontinued. The healing frequency in patients with gastric ulceration was 67, 68 and 47%, and in those with duodenal ulceration 61, 81 and 42%, respectively. Only the difference between the duodenal ulcer healing rates for ranitidine with NSAID discontinued and placebo was statistically significant (P = 0.02). Healing rates were uninfluenced by gender, age, smoking habits, alcohol consumption, ulcer frequency or size, arthritic disease, or participating country. |
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Authors:
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G Tildesley; R S Ehsanullah; J R Wood |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of rheumatology Volume: 32 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-07-13 Completed Date: 1993-07-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 474-8 Citation Subset: AIM; IM |
Affiliation:
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Hartlepool General Hospital, Cleveland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal / adverse effects*, therapeutic use Arthritis / drug therapy* Double-Blind Method Drug Administration Schedule Duodenal Ulcer / complications, drug therapy*, etiology Female Humans Male Middle Aged Prospective Studies Ranitidine / administration & dosage*, adverse effects Stomach Ulcer / complications, drug therapy*, etiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 66357-35-5/Ranitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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