Document Detail

Ranitidine improves lymphocyte function after severe head injury: results of a randomized, double-blind study.
MedLine Citation:
PMID:  8917026     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the immunomodulatory effect of the histamine receptor antagonist, ranitidine, in patients admitted to the intensive care unit after severe head injury. DESIGN: Randomized, prospective, double-blind study. SETTING: Surgical intensive care unit of a university Level I trauma center. PATIENTS: Twenty patients admitted with a Glasgow Coma Scale score of < 10 who were enrolled as part of a prospective, multicenter trial to assess the impact of multiple risk factors and ranitidine prophylaxis on the development of stress-related upper gastrointestinal bleeding. INTERVENTIONS: Continuous infusion of ranitidine at 6.25 mg/hr (n = 9) or placebo (n = 11) for a maximum of 5 days. MEASUREMENTS AND MAIN RESULTS: Before the patients were enrolled in the study and on completion of treatment, lymphocyte cell-surface antigen expression was determined by flow cytometry (n = 14 patients); mitogen-stimulated interferon-gamma and interleukin-2 production were measured by enzyme-linked immunosorbent assay (n = 19 patients). Treatment with ranitidine, but not placebo, was associated with a significant increase in CD4+ lymphocytes (33% to 49%; p < .05) and a significant decrease in CD8+ lymphocytes (41% to 27%; p < .05). Also, the mitogen-stimulated interferon-gamma production increased from 121 to 269 pg/mL (p < .05) in patients treated with ranitidine, but not in patients treated with placebo. There were no significant differences in interleukin-2 production or circulating B-cell concentrations between both groups. CONCLUSION: This study demonstrates an immunostimulatory effect of the histamine-2-receptor antagonist, ranitidine, both at the cellular and mediator levels in patients after head injury.
D Rixen; D H Livingston; P Loder; T N Denny
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  24     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1787-92     Citation Subset:  AIM; IM    
Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, USA.
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MeSH Terms
CD4-Positive T-Lymphocytes / drug effects*,  physiology
Craniocerebral Trauma / complications*
Double-Blind Method
Gastrointestinal Hemorrhage / etiology*,  prevention & control*
Glasgow Coma Scale
Histamine H2 Antagonists / administration & dosage,  therapeutic use*
Infusions, Intravenous
Injury Severity Score
Interferon-gamma / biosynthesis
Middle Aged
Prospective Studies
Ranitidine / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Histamine H2 Antagonists; 66357-35-5/Ranitidine; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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