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RANIBIZUMAB FOR THE TREATMENT OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH RETINAL PIGMENT EPITHELIAL TEAR.
MedLine Citation:
PMID:  21427630     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE:: To evaluate the efficacy of intravitreal ranibizumab in eyes with exudative age-related macular degeneration associated with retinal pigment epithelial tear. METHODS:: In this retrospective case series, patients with active exudative age-related macular degeneration associated with retinal pigment epithelial tear were treated by repeated injections of intravitreal ranibizumab. The outcome measures were best-corrected visual acuity and the signs of lesion activity, as evaluated by optical coherence tomography, fluorescein angiography, and indocyanine green angiography. RESULTS:: Twenty-one eyes of 20 patients were followed-up for a median of 12 months (range, 6-28 months). The median number of injections was 7 (range, 3-15). The best-corrected visual acuity improved in 6 eyes (28.57%), remained stable in 12 (57.14%), and decreased in 3 (14.28%). At the end of the follow-up time, 19 eyes (90.47%) had an inactive neovascular lesion in angiography, while 18 eyes (85.71%) had no signs of intraretinal or subretinal fluid. CONCLUSION:: Intravitreal ranibizumab was effective in improving or stabilizing vision and resulting in a quiescent lesion in the majority of patients with exudative age-related macular degeneration associated with retinal pigment epithelial tear. The functional results were apparently better in eyes without foveal involvement by the retinal pigment epithelial tear.
Authors:
Alexandros A Rouvas; Ioannis D Ladas; Ilias Georgalas; Ioannis Vergados; Dimitrios Papakonstantinou; Athanasios I Kotsolis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-19
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  -     ISSN:  1539-2864     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the *Second Department of Ophthalmology; and †First Department of Ophthalmology, Medical School of Athens University, Athens, Greece.
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