| RANIBIZUMAB FOR THE TREATMENT OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH RETINAL PIGMENT EPITHELIAL TEAR. | |
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MedLine Citation:
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PMID: 21427630 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:: To evaluate the efficacy of intravitreal ranibizumab in eyes with exudative age-related macular degeneration associated with retinal pigment epithelial tear. METHODS:: In this retrospective case series, patients with active exudative age-related macular degeneration associated with retinal pigment epithelial tear were treated by repeated injections of intravitreal ranibizumab. The outcome measures were best-corrected visual acuity and the signs of lesion activity, as evaluated by optical coherence tomography, fluorescein angiography, and indocyanine green angiography. RESULTS:: Twenty-one eyes of 20 patients were followed-up for a median of 12 months (range, 6-28 months). The median number of injections was 7 (range, 3-15). The best-corrected visual acuity improved in 6 eyes (28.57%), remained stable in 12 (57.14%), and decreased in 3 (14.28%). At the end of the follow-up time, 19 eyes (90.47%) had an inactive neovascular lesion in angiography, while 18 eyes (85.71%) had no signs of intraretinal or subretinal fluid. CONCLUSION:: Intravitreal ranibizumab was effective in improving or stabilizing vision and resulting in a quiescent lesion in the majority of patients with exudative age-related macular degeneration associated with retinal pigment epithelial tear. The functional results were apparently better in eyes without foveal involvement by the retinal pigment epithelial tear. |
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Authors:
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Alexandros A Rouvas; Ioannis D Ladas; Ilias Georgalas; Ioannis Vergados; Dimitrios Papakonstantinou; Athanasios I Kotsolis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-19 |
Journal Detail:
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Title: Retina (Philadelphia, Pa.) Volume: - ISSN: 1539-2864 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309919 Medline TA: Retina Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Second Department of Ophthalmology; and †First Department of Ophthalmology, Medical School of Athens University, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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