| Randomly allocated study of the effects of standard therapy versus ACE inhibition on micro-albuminuria in essential hypertension. | |
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MedLine Citation:
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PMID: 7965276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effects of standard therapy (diuretic, beta-blocker or both) with those of angiotensin converting enzyme (ACE) inhibition with quinapril on renal function and urinary albumin excretion in patients with essential hypertension. METHODS: A 1-year, placebo-controlled, randomly allocated study was conducted in a group of 40 patients with essential hypertension. Before beginning the active treatment phase, all patients were given a matched placebo for quinapril for at least 14 days. At baseline and after 1, 3, 6 and 12 months of treatment, blood pressure, heart rate, body weight, renal plasma flow, glomerular filtration rate, plasma renin activity, plasma aldosterone and urinary albumin excretion were measured. RESULTS: Both the standard therapy and quinapril produced similar decreases in blood pressure, but only quinapril produced a significant decrease in micro-albuminuria, from 68.5 +/- 16.7 to 47.2 +/- 14.9 mg/24 h (P < 0.05). The renal plasma flow remained constant in both study groups while the glomerular filtration rate and filtration fraction decreased significantly (P < 0.05) in the quinapril group. CONCLUSIONS: The results of this study indicate that long-term therapy for essential hypertension with ACE inhibition has a more favorable effect on micro-albuminuria than standard therapy for an equal level of blood pressure control. |
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Authors:
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L M Ruilope; V Lahera; J M Alcázar; M Praga; C Campo; J L Rodicio |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 12 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-12-29 Completed Date: 1994-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S59-63 Citation Subset: IM |
Affiliation:
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Unidad de Hipertension, Hospital 12 de Octubre, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Albuminuria / drug therapy*, etiology*, urine Aldosterone / blood Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Blood Pressure / drug effects Diuretics / therapeutic use* Female Glomerular Filtration Rate / drug effects Humans Hypertension / complications*, physiopathology Male Middle Aged Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Diuretics; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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