Document Detail

Randomized trial of vaginal prostaglandin E2 versus oxytocin for labor induction in term premature rupture of membranes.
MedLine Citation:
PMID:  20466294     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to compare the efficacy and safety of a prostaglandin E(2) (PGE(2)) vaginal insert with those of oxytocin for labor induction. The present study also examined whether its use reduces the rate of cesarean delivery in term pregnancies with premature rupture of membranes (PROM) and low Bishop scores. MATERIALS AND METHODS: A total of 240 women with singleton pregnancies at >or= 37 weeks, no prior uterine scar, vertex presentations, reactive nonstress tests, PROM for >or= 12 hours and Bishop scores of <or= 6 were randomly assigned to receive either oxytocin or vaginal PGE(2). The primary outcomes were time from induction to delivery and mode of delivery. RESULTS: The time from labor induction to active labor onset was significantly shorter in the oxytocin group than in the PGE(2) group (4.9 +/- 4.1 vs. 8.5 +/- 3.6 hours; p = 0.02). The time from induction to delivery was also significantly shorter in the oxytocin group (3.4 +/- 1.5 vs. 9.6 +/- 4.7 hours; p = 0.02). Cesarean delivery rates were statistically similar in the oxytocin and PGE(2) groups (18.3 vs. 20.0%; p = 0.81). Neonatal outcomes were comparable in both groups. Comparable results were observed for nulliparous women included in the study population. CONCLUSION: Oxytocin treatment seems to be superior to vaginal administration of PGE(2) to induce labor in term pregnancies complicated with PROM and unfavorable services.
Cigdem Kunt; Mine Kanat-Pektas; Ayse Nur Cakir Gungor; Raziye Keskin Kurt; Mustafa Ozat; Cavidan Gulerman; Tayfun Gungor; Leyla Mollamahmutoglu
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Taiwanese journal of obstetrics & gynecology     Volume:  49     ISSN:  1875-6263     ISO Abbreviation:  Taiwan J Obstet Gynecol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101213819     Medline TA:  Taiwan J Obstet Gynecol     Country:  China    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Copyright Information:
(c) 2010 Taiwan Association of Obstetric & Gynecology. Published by Elsevier B.V. All rights reserved.
Department of Perinatology, Dr Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey.
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MeSH Terms
Administration, Intravaginal
Cesarean Section / statistics & numerical data
Dinoprostone / therapeutic use*
Fetal Membranes, Premature Rupture / therapy*
Infant, Newborn
Labor, Induced / methods*
Labor, Obstetric
Oxytocics / therapeutic use*
Oxytocin / therapeutic use*
Time Factors
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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