Document Detail

Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda.
MedLine Citation:
PMID:  11717659     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to assess presumptive sexually transmitted disease treatment on pregnancy outcome and HIV transmission. STUDY DESIGN: In a randomized trial in Rakai District, Uganda, 2070 pregnant women received presumptive sexually transmitted disease treatment 1 time during pregnancy at varying gestations, and 1963 control mothers received iron/folate and referral for syphilis. Maternal-infant sexually transmitted disease/HIV and infant outcomes were assessed. Intent-to-treat analyses estimated adjusted rate ratios and 95% confidence intervals. RESULTS: Sexually transmitted diseases were reduced: Trichomonas vaginalis (rate ratio, 0.28; 95% CI, 0.18%-0.49%), bacterial vaginosis (rate ratio, 0.78; 95% CI, 0.69-0.87), Neisseria gonorrhoeae /Chlamydia trachomatis (rate ratio, 0.43; 95% CI, 0.27-0.68), and infant ophthalmia (rate ratio, 0.37; 95% CI, 0.20-0.70). There were reduced rates of neonatal death (rate ratio, 0.83; 95% CI, 0.71-0.97), low birth weight (rate ratio, 0.68; 95% CI, 0.53-0.86), and preterm delivery (rate ratio, 0.77; 95% CI, 0.56-1.05); but there were no effects on maternal HIV acquisition or perinatal HIV transmission. CONCLUSION: Reductions of maternal sexually transmitted disease improved pregnancy outcome but not maternal HIV acquisition or perinatal HIV transmission.
R H Gray; F Wabwire-Mangen; G Kigozi; N K Sewankambo; D Serwadda; L H Moulton; T C Quinn; K L O'Brien; M Meehan; C Abramowsky; M Robb; M J Wawer
Related Documents :
24953519 - Impact of periodontal therapy on general health: evidence from insurance data for five ...
24057769 - The treatment of hypertension during pregnancy: when should blood pressure medications ...
17344509 - Maternal vitamin d intake during pregnancy and early childhood wheezing.
23272429 - Comparison of manual vacuum aspiration, and dilatation and curettage in the treatment o...
25124209 - Adolescent pregnancy and contraception.
20048009 - Proliferation of prenatal ultrasonography.
1492909 - Predictive value of uterine artery velocity waveforms in pregnancies complicated by sys...
15986719 - The effects of tobacco use during and after pregnancy on exposed children.
11923079 - Evolution of viviparity: what can australian lizards tell us?
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  185     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-21     Completed Date:  2001-12-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1209-17     Citation Subset:  AIM; IM    
Department of Population and Family Health Sciences, The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md 21205, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Azithromycin / therapeutic use*
Birth Weight
Cefixime / therapeutic use*
Drug Therapy, Combination
Endophthalmitis / prevention & control
Folic Acid / therapeutic use
HIV Infections / therapy
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases / prevention & control
Infant, Premature
Iron / therapeutic use
Metronidazole / therapeutic use*
Obstetric Labor, Premature / prevention & control
Pregnancy Complications, Infectious / therapy*
Sexually Transmitted Diseases / prevention & control,  therapy*
Grant Support
Reg. No./Substance:
443-48-1/Metronidazole; 59-30-3/Folic Acid; 7439-89-6/Iron; 79350-37-1/Cefixime; 83905-01-5/Azithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intrapartum management of nonvertex second-born twins: a critical analysis.
Next Document:  The distribution, practice, and attitudes of maternal-fetal medicine specialists.