| Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. | |
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MedLine Citation:
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PMID: 11717659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to assess presumptive sexually transmitted disease treatment on pregnancy outcome and HIV transmission. STUDY DESIGN: In a randomized trial in Rakai District, Uganda, 2070 pregnant women received presumptive sexually transmitted disease treatment 1 time during pregnancy at varying gestations, and 1963 control mothers received iron/folate and referral for syphilis. Maternal-infant sexually transmitted disease/HIV and infant outcomes were assessed. Intent-to-treat analyses estimated adjusted rate ratios and 95% confidence intervals. RESULTS: Sexually transmitted diseases were reduced: Trichomonas vaginalis (rate ratio, 0.28; 95% CI, 0.18%-0.49%), bacterial vaginosis (rate ratio, 0.78; 95% CI, 0.69-0.87), Neisseria gonorrhoeae /Chlamydia trachomatis (rate ratio, 0.43; 95% CI, 0.27-0.68), and infant ophthalmia (rate ratio, 0.37; 95% CI, 0.20-0.70). There were reduced rates of neonatal death (rate ratio, 0.83; 95% CI, 0.71-0.97), low birth weight (rate ratio, 0.68; 95% CI, 0.53-0.86), and preterm delivery (rate ratio, 0.77; 95% CI, 0.56-1.05); but there were no effects on maternal HIV acquisition or perinatal HIV transmission. CONCLUSION: Reductions of maternal sexually transmitted disease improved pregnancy outcome but not maternal HIV acquisition or perinatal HIV transmission. |
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Authors:
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R H Gray; F Wabwire-Mangen; G Kigozi; N K Sewankambo; D Serwadda; L H Moulton; T C Quinn; K L O'Brien; M Meehan; C Abramowsky; M Robb; M J Wawer |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 185 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-21 Completed Date: 2001-12-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1209-17 Citation Subset: AIM; IM |
Affiliation:
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Department of Population and Family Health Sciences, The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md 21205, USA. rgray@jhsph.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Azithromycin
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therapeutic use* Birth Weight Cefixime / therapeutic use* Drug Therapy, Combination Endophthalmitis / prevention & control Female Folic Acid / therapeutic use HIV Infections / therapy Humans Infant Infant Mortality Infant, Newborn Infant, Newborn, Diseases / prevention & control Infant, Premature Iron / therapeutic use Metronidazole / therapeutic use* Obstetric Labor, Premature / prevention & control Pregnancy Pregnancy Complications, Infectious / therapy* Sexually Transmitted Diseases / prevention & control, therapy* Uganda |
| Grant Support | |
ID/Acronym/Agency:
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5D43TW00010/TW/FIC NIH HHS; 5P30HD06826/HD/NICHD NIH HHS; R01 AI3426S/AI/NIAID NIH HHS; R01 AI34826/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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443-48-1/Metronidazole; 59-30-3/Folic Acid; 7439-89-6/Iron; 79350-37-1/Cefixime; 83905-01-5/Azithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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