Document Detail

Randomized trial of intracervical prostaglandin E2 gel and intraamniotic prostaglandin F2 alpha for induction of second trimester abortion.
MedLine Citation:
PMID:  6586395     Owner:  NLM     Status:  MEDLINE    
For the purpose of reducing the side effects and complication rate when inducing second trimester abortion, intracervically administered PGE2 gel was tested for the first time and compared with a single intraamniotic instillation of PGF2 alpha by a randomized allocation of 41 consecutive patients in the 13th to 24th week of gestation. In both groups the treatment was supplemented with oxytocin 5 - 6 hours after starting the induction. The methods proved of equal value as regards the abortion success rate and the induction-abortion interval, whereas the incidence of gastrointestinal side effects on intracervical application of PGE2 gel was only half as high and the occurrence of diarrhea significantly lower (p less than 0.05) with this non-invasive method than with intraamniotic PGF2 alpha. Intracervical PGE2 gel also possessed other advantages, being int. al. more acceptable by the patients and technically easier to administer.
S Stampe Sørensen; P Wolf
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Contraception     Volume:  29     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-07-23     Completed Date:  1984-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-9     Citation Subset:  IM    
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MeSH Terms
Abortion, Induced*
Cervix Uteri
Pregnancy Trimester, Second
Prostaglandins E / administration & dosage*,  adverse effects
Prostaglandins F / administration & dosage*,  adverse effects
Random Allocation
Reg. No./Substance:
0/Gels; 0/Prostaglandins E; 0/Prostaglandins F; 363-24-6/Dinoprostone; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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