Document Detail

Randomized trial of high-dose cytarabine versus amsacrine in acute myelogenous leukemia in relapse: a Leukemia Intergroup Study.
MedLine Citation:
PMID:  3516395     Owner:  NLM     Status:  MEDLINE    
Patients with acute myelogenous leukemia in relapse who were ineligible for further anthracycline therapy either because they were judged to be anthracycline resistant or had received the maximum doses were randomized to receive high-dose cytarabine (3 g/m2 every 12 hours for 6 days) or amsacrine (75 mg/m2 daily for 7 days). The response rates in both groups were similar: three of 25 patients given high-dose cytarabine and three of 23 given amsacrine obtained complete remissions.
W R Vogler; H D Preisler; E F Winton; A J Gottlieb; J Goldberg; J Brennan; H Grunwald; K Rai; G Browman; K B Miller
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cancer treatment reports     Volume:  70     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-19     Completed Date:  1986-06-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-9     Citation Subset:  IM    
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MeSH Terms
Aminoacridines / adverse effects,  therapeutic use*
Antibiotics, Antineoplastic / therapeutic use
Bone Marrow / pathology
Clinical Trials as Topic
Cytarabine / administration & dosage*,  adverse effects
Drug Resistance
Leukemia, Myeloid, Acute / drug therapy*,  pathology
Middle Aged
Naphthacenes / therapeutic use
Random Allocation
Reg. No./Substance:
0/Aminoacridines; 0/Antibiotics, Antineoplastic; 0/Naphthacenes; 147-94-4/Cytarabine; 51264-14-3/Amsacrine

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