Document Detail

Randomized trial examining cerebral haemodynamics following artificial or animal surfactant.
MedLine Citation:
PMID:  9628297     Owner:  NLM     Status:  MEDLINE    
To determine the effects of animal and artificial surfactants on cerebral haemodynamics, 20 premature babies receiving mechanical ventilation were randomized to receive Curosurf or Exosurf surfactant. Anterior cerebral artery blood flow velocity (CABFV) was measured using Doppler ultrasound before and up to 2 h after treatment. Following animal surfactant there was a rapid reduction in CABFV (median -36%, range -43% to +8%, p < 0.01), whereas artificial surfactant resulted in a slower rise which was less marked (median +20%, range -7% to +62%, p < 0.05). There were no significant changes in blood pressure. Two hours after administration, the oxygenation index (OI) improved significantly only in babies receiving animal surfactant. In this group there was a significant association between the change in CABFV at 1 min and the change in OI at 2h (r = 0.66, p < 0.05). Animal surfactant produces rapid improvements in ventilation which are associated with marked alterations in cerebral haemodynamics.
E Murdoch; S T Kempley
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  87     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-30     Completed Date:  1998-07-30     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  411-5     Citation Subset:  IM    
Neonatal Unit, Royal London Hospital, Whitechapel, UK.
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MeSH Terms
Biological Agents*
Cerebral Arteries / physiology
Cerebrovascular Circulation / drug effects*
Drug Combinations
Fatty Alcohols / pharmacology*,  therapeutic use
Hemodynamics / drug effects
Infant, Newborn
Infant, Premature
Intermittent Positive-Pressure Ventilation
Polyethylene Glycols / pharmacology*,  therapeutic use
Pulmonary Surfactants / pharmacology*,  therapeutic use
Regional Blood Flow / drug effects
Respiratory Distress Syndrome, Newborn / drug therapy*
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Agents; 0/Drug Combinations; 0/Fatty Alcohols; 0/Phospholipids; 0/Polyethylene Glycols; 0/Pulmonary Surfactants; 107-73-3/Phosphorylcholine; 99732-49-7/dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination; KE3U2023NP/poractant alfa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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