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Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne.
MedLine Citation:
PMID:  21896127     Owner:  NLM     Status:  In-Data-Review    
Background  Lipohydroxyacid is a lipophilic derivative of salicylic acid with comedolytic properties. Objectives  To compare lipohydroxyacid and salicylic acid peels in subjects with comedonal acne. Methods  In this split face, randomized study, 20 subjects with comedonal acne received lipohydroxyacid peels on one side of the face, while the other side was treated with salicylic acid peels. A total of six peels at 2-week intervals were performed. Efficacy was evaluated by counting noninflammatory and inflammatory lesions and by performing a global change in acne assessment. Safety was assessed by evaluating adverse events, global tolerance, and the presence of erythema, scaling, and dryness. Results  There was a statistically significant decrease of 55.6% and 48.5% from baseline to Day 98 in the mean number of noninflammatory lesions for the sides treated with lipohydroxyacid and salicylic acid peels, respectively (P < 0.001). There was no significant difference in the degree of reduction in noninflammatory lesions between the two peels. There was no significant reduction in the number of inflammatory lesions. Both peels were generally very well tolerated. Conclusion  This study suggests that lipohydroxyacid peels can be beneficial to subjects with comedonal acne.
Annie Levesque; Iltefat Hamzavi; Sophie Seite; André Rougier; Robert Bissonnette
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cosmetic dermatology     Volume:  10     ISSN:  1473-2165     ISO Abbreviation:  J Cosmet Dermatol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130964     Medline TA:  J Cosmet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Innovaderm Research Inc., Montreal Quebec, Canada Hamzavi Dermatology, Fort Gratiot, MI, USA La Roche-Posay Laboratoire Pharmaceutique, Asnières Cedex, France.
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