Document Detail

Randomized trial of alcohol versus triple dye for umbilical cord care.
MedLine Citation:
PMID:  12166794     Owner:  NLM     Status:  MEDLINE    
Over a 4-month period, all infants admitted to the well-baby nursery were enrolled in a prospective study designed to compare cord separation times between infants treated with triple dye once, followed by daily alcohol application, to infants treated with daily alcohol application alone. Follow-up phone calls were done 7 days after discharge, with weekly calls until cord separation occurred. The objective was to determine whether the umbilical cord care regimen of triple dye followed by alcohol has an advantage over the alternative regimen of alcohol alone, with regard to cord separation, parenting, or healthcare caretaker preferences. In total, 634 infants were enrolled, with 599 infants (94%) completing the study. Infants in the alcohol alone group had a shorter cord separation time by 3 days (10 versus 13 days) (p < 0.0001). There was no reported increase in infection, and monetary savings were noted. We conclude that alcohol applied once a day appears to be a safe and effective means of promoting cord detachment.
Sergio G Golombek; Patricia E Brill; Anne L Salice
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical pediatrics     Volume:  41     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-08-08     Completed Date:  2003-01-16     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  AIM; IM    
The Regional Neonatal Center-New York Medical College, Westchester Medical Center-Valhalla, 10595, USA.
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MeSH Terms
Administration, Topical
Alcohols / therapeutic use*
Anti-Infective Agents, Local / therapeutic use*
Chi-Square Distribution
Drug Combinations
Follow-Up Studies
Gentian Violet / therapeutic use*
Infant, Newborn
Proflavine / therapeutic use*
Prospective Studies
Quaternary Ammonium Compounds / therapeutic use*
Reference Values
Statistics, Nonparametric
Treatment Outcome
Umbilical Cord / drug effects*
Wound Healing / drug effects,  physiology
Wound Infection / prevention & control*
Reg. No./Substance:
0/Alcohols; 0/Anti-Infective Agents, Local; 0/Drug Combinations; 0/Quaternary Ammonium Compounds; 39389-84-9/Triple Dye; 548-62-9/Gentian Violet; 92-62-6/Proflavine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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