Document Detail

Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension.
MedLine Citation:
PMID:  16998266     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mega trials of rhythm vs rate control could not demonstrate the usefulness of available antiarrhythmic drugs, so a more effective and safer therapy for atrial fibrillation (AF) is now required. One candidate is the so-called "upstream therapy", which refers to the blockade of upstream modifying elements (renin - angiotensin system, cathecholamines, oxidative stress etc) that contribute to the arrhythmogenic substrate.
METHODS AND RESULTS: The Japanese Rhythm Management Trial II for Atrial Fibrillation (J-RHYTHM II study) is a randomized comparative evaluation of an angiotensin II type 1 blocker (candesartan) and a dihydropiridine calcium blocker (amlodipine), both combined with antithrombotic therapy, as an antiarrhythmic therapy for the treatment of paroxysmal AF (PAF) associated with hypertension. To test the usefulness of this therapy, this study will reveal the recurrence rate of asymptomatic as well as symptomatic PAF during 1-year of treatment with candesartan or amlodipine, using daily transtelephonic monitoring.
CONCLUSIONS: The J-RHYTHM II study will follow 400 patients with PAF and hypertension who were treated at approximately 50 sites throughout Japan, and will provide clinically important information.
Takeshi Yamashita; Satoshi Ogawa; Yoshifusa Aizawa; Hirotsugu Atarashi; Hiroshi Inoue; Tohru Ohe; Ken Okumura; Hiroshi Ohtsu; Takao Kato; Shiro Kamakura; Koichiro Kumagai; Yoshihisa Kurachi; Itsuo Kodama; Yukihiro Koretsune; Tetsunori Saikawa; Masayuki Sakurai; Kaoru Sugi; Haruaki Nakaya; Makoto Hirai; Atsushi Hirayama; Masahiko Fukatani; Hideo Mitamura; Tsutomu Yamazaki; Eiichi Watanabe;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  70     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-11-22     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1318-21     Citation Subset:  IM    
J-RHYTHM II Clinical Trial Center, The Cardiovascular Institute, Roppongi, Tokyo, Japan.
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MeSH Terms
Amlodipine / administration & dosage
Angiotensin II Type 1 Receptor Blockers / administration & dosage*
Atrial Fibrillation / drug therapy*
Benzimidazoles / administration & dosage
Calcium Channel Blockers / administration & dosage*
Dihydropyridines / administration & dosage
Hypertension / complications,  drug therapy*
Recurrence / prevention & control
Tetrazoles / administration & dosage
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Benzimidazoles; 0/Calcium Channel Blockers; 0/Dihydropyridines; 0/Tetrazoles; 7M8K3P6I89/1,4-dihydropyridine; 88150-42-9/Amlodipine; S8Q36MD2XX/candesartan

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