| Randomized placebo-controlled trial of teicoplanin in the antibiotic prophylaxis of infection following manipulation of burn wounds. | |
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MedLine Citation:
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PMID: 9189106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Burn wound surgery or change of dressings commonly causes bacteraemia. The use of antibiotic prophylaxis has not been tested adequately in a controlled trial. METHODS: A randomized double-blind placebo-controlled study was performed to determine the effect on Gram-positive bacteraemia and clinical outcome of a single dose of teicoplanin (12 mg/kg intravenously) given at burns surgery or change of dressings. RESULTS: A total of 134 patients were entered into the study, representing 220 episodes of dressing or debridement (110 episodes in each group). There was a significant difference between the groups with respect to perioperative Gram-positive bacteraemia: eight episodes (7 per cent) in the teicoplanin group versus 51 (46 per cent) in the placebo group (P < 0.001). However, good clinical outcome was similar in both groups (80 of 110 versus 77 of 110 respectively, P = 0.7). Only eleven patients had bacteraemia caused by Gram-negative species alone. Bacteriological response in terms of wound culture showed no significant difference between the groups: 63 (57 per cent) of 110 episodes versus 58 (53 per cent) of 110 respectively respectively. CONCLUSION: Prevention of Gram-positive bacteraemia did not affect postoperative recovery. |
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Authors:
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J A Steer; R P Papini; A P Wilson; D A McGrouther; L S Nakhla; N Parkhouse |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of surgery Volume: 84 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-07 Completed Date: 1997-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 848-53 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Microbiology, University College London Hospitals, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / adverse effects, therapeutic use* Antibiotic Prophylaxis* / adverse effects Bacteremia / prevention & control Bacterial Infections / prevention & control* Burns / microbiology, surgery* Double-Blind Method Drug Resistance, Microbial Female Humans Male Middle Aged Teicoplanin / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 61036-62-2/Teicoplanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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