| Randomized double-blind study of fluvoxamine and maprotiline in treatment of depression. | |
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MedLine Citation:
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PMID: 1901418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a six-week double-blind randomized trial, preceded by a one-week period of single-blind placebo treatment, the efficacy and the side-effects of fluvoxamine (100-300 mg/d) (n = 24) and maprotiline (50-150 mg/d) (n = 24) were compared in moderately depressed outpatients with DSM-III Major Depression (n = 22) or Dysthymic Disorder (n = 26). Efficacy was measured by means of the Hamilton Depression Rating Scale, the Zung Depression Selfrating Scale, and a Clinical Global Impression of Severity Scale. Side-effects were evaluated by an Adverse Event Inventory and a Psychosomatic Symptom Scale. A statistically significant improvement was achieved in both treatment groups but success rates were modest: in both groups, 29% of the patients achieved a clinically significant improvement after six weeks of treatment. After six weeks of treatment, no difference in efficacy was found between fluvoxamine and maprotiline. Nausea was the most common complaint in the fluvoxamine group, while in the maprotiline group, it was dry mouth and constipation. One maprotiline-treated patient developed a convulsive attack. |
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Authors:
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F de Jonghe; J Swinkels; H Tuynman-Qua |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Pharmacopsychiatry Volume: 24 ISSN: 0176-3679 ISO Abbreviation: Pharmacopsychiatry Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-05-09 Completed Date: 1991-05-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8402938 Medline TA: Pharmacopsychiatry Country: GERMANY |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antidepressive Agents / adverse effects, therapeutic use* Depression / drug therapy*, psychology Double-Blind Method Female Fluvoxamine Humans Male Maprotiline / adverse effects, therapeutic use* Middle Aged Oximes / adverse effects, therapeutic use* Psychiatric Status Rating Scales |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Oximes; 10262-69-8/Maprotiline; 54739-18-3/Fluvoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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