| Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection. | |
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MedLine Citation:
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PMID: 16940855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In children, zinc supplementation reduces the incidence and severity of diarrhea. METHODS: HIV-infected adults with > or =7 days of diarrhea recruited at 3 tertiary hospitals in Lima, Peru, received a zinc sulfate capsule containing 50 mg of elemental zinc twice daily or an identical placebo for 14 days. Outcomes included persistence of diarrhea at day 14 and time until cessation of diarrhea. RESULTS: The 81 subjects randomized to zinc and 78 randomized to placebo were comparable at baseline, except for higher prevalences of certain enteric pathogens in the zinc group; complete follow-up rates were 62% and 69%, respectively. Zinc concentrations were consistent with zinc deficiency at follow-up in 94% of placebo recipients and 66% of zinc recipients (P = 0.01). Persistence of diarrhea at day 14 according to follow-up interview (60% for zinc-treated patients and 57.4% for placebo-treated patients) or to patient diary (42.2% vs. 31.9%) did not differ significantly. Adjusting for enteric pathogens and CD4 count, the hazard ratio (HR) for zinc supplementation and cessation of diarrhea (according to the diaries) was 0.91 (95% confidence interval [CI]: 0.50 to 1.64). CONCLUSION: Supplemental zinc had no significant effect on the duration or remission of diarrhea in HIV-infected adults. |
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Authors:
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César Cárcamo; Thomas Hooton; Noel S Weiss; Robert Gilman; Mark H Wener; Victor Chavez; Rosario Meneses; Juan Echevarria; Margot Vidal; King K Holmes |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 43 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-27 Completed Date: 2006-11-28 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 197-201 Citation Subset: IM; X |
Affiliation:
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Department of Epidemiology, University of Washington, Seattle, WA 98104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diarrhea / drug therapy*, epidemiology, etiology Dietary Supplements Drug Administration Schedule Female HIV Infections / complications* Humans Male Middle Aged Outcome Assessment (Health Care) Placebos Zinc / administration & dosage, deficiency, therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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D43 TW00007-06/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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