| Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. | |
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MedLine Citation:
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PMID: 15288885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A double-blind randomized controlled trial was carried out to assess the effect of sour milk, containing two tripeptides (valine-proline-proline and isoleucine-proline-proline), on blood pressure (BP). METHODS: A total of 46 borderline hypertensive men aged 23 to 59 years were recruited at their workplace for this trial. Subjects were randomly allocated into two groups; sour milk drink group (S-group, n = 23) and placebo (acidified milk) drink group (P-group, n = 23) for 4 weeks. Blood pressure was measured twice at each occasion by a physician, at the health center of the company, with a mercury at baseline, 2 and 4 weeks. Statistical analysis was performed by SPSS 10.0J. RESULTS: The S-group and P-group showed no significant difference in baseline systolic BP (mean [SD], S: 147.6 [9.6], P: 145.3 [13.0]) or diastolic BP (S: 95.3 [9.9], P: 91.5 [9.6]). In the S-group, change in systolic BP at 2 and 4 weeks were -4.3 mm Hg (95% confidence interval [CI] -8.3 to -0.4; P = .032) and -5.2 mm Hg (95% CI -10.1 to -0.3; P = .039), both statistically significant. Diastolic BP showed change from -1.7 mm Hg (95% CI -5.4 to 2.0) at 2 weeks and -2.0 (95% CI -5.4 to 1.5) at 4 weeks, respectively. In the P-group, change in systolic BP were -0.5 (95% CI -5.8 to 4.8) at 2 weeks and -3.7 (95% CI -8.3 to 0.9) and change in diastolic BP were -0.6 (95% CI -4.7 to 3.6) and -0.3 (95% CI -3.9 to 3.3), which were not statistically significant. CONCLUSIONS: This trial demonstrated the beneficial effect of sour milk on BP in borderline hypertensive men who were not taking antihypertensive medication. |
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Authors:
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Shunsaku Mizushima; Kenji Ohshige; Junko Watanabe; Maki Kimura; Takashi Kadowaki; Yasunori Nakamura; Osamu Tochikubo; Hirotsugu Ueshima |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of hypertension Volume: 17 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2005-01-14 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 701-6 Citation Subset: IM |
Copyright Information:
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Copyright 2004 American Journal of Hypertension, Ltd. |
Affiliation:
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International Research Center for Medical Education, The University of Tokyo, Tokyo, Japan. shunsaku-tky@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Blood Pressure* Dietary Supplements Humans Hypertension / diet therapy* Male Middle Aged Milk* / adverse effects Patient Compliance |
| Comments/Corrections | |
Comment In:
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Am J Hypertens. 2005 Jul;18(7):1015
[PMID:
16054002
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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