Document Detail


Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity.
MedLine Citation:
PMID:  23541163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Mindfulness meditation has met increasing interest as a therapeutic strategy for anxiety disorders, but prior studies have been limited by methodological concerns, including a lack of an active comparison group. This is the first randomized, controlled trial comparing the manualized Mindfulness-Based Stress Reduction (MBSR) program with an active control for generalized anxiety disorder (GAD), a disorder characterized by chronic worry and physiologic hyperarousal symptoms.
METHOD: Ninety-three individuals with DSM-IV-diagnosed GAD were randomly assigned to an 8-week group intervention with MBSR or to an attention control, Stress Management Education (SME), between 2009 and 2011. Anxiety symptoms were measured with the Hamilton Anxiety Rating Scale (HAMA; primary outcome measure), the Clinical Global Impressions-Severity of Illness and -Improvement scales (CGI-S and CGI-I), and the Beck Anxiety Inventory (BAI). Stress reactivity was assessed by comparing anxiety and distress during pretreatment and posttreatment administration of the Trier Social Stress Test (TSST).
RESULTS: A modified intent-to-treat analysis including participants who completed at least 1 session of MBSR (n = 48) or SME (n = 41) showed that both interventions led to significant (P < .0001) reductions in HAMA scores at endpoint, but did not significantly differ. MBSR, however, was associated with a significantly greater reduction in anxiety as measured by the CGI-S, the CGI-I, and the BAI (all P values < .05). MBSR was also associated with greater reductions than SME in anxiety and distress ratings in response to the TSST stress challenge (P < .05) and a greater increase in positive self-statements (P = .004).
CONCLUSIONS: These results suggest that MBSR may have a beneficial effect on anxiety symptoms in GAD and may also improve stress reactivity and coping as measured in a laboratory stress challenge.
TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01033851.
Authors:
Elizabeth A Hoge; Eric Bui; Luana Marques; Christina A Metcalf; Laura K Morris; Donald J Robinaugh; John J Worthington; Mark H Pollack; Naomi M Simon
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  74     ISSN:  1555-2101     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-09-11     Completed Date:  2013-10-29     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  786-92     Citation Subset:  IM    
Copyright Information:
© Copyright 2013 Physicians Postgraduate Press, Inc.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01033851
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Psychological
Adult
Anxiety Disorders / diagnosis,  psychology,  therapy*
Arousal*
Awareness*
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Interview, Psychological
Male
Meditation / methods*,  psychology*
Middle Aged
Patient Education as Topic
Problem Solving
Questionnaires
Self Concept
Social Environment
Speech
Stress, Psychological / complications*,  psychology*
Yoga / psychology
Grant Support
ID/Acronym/Agency:
K23 AT004432/AT/NCCAM NIH HHS; UL1 RR 025758/RR/NCRR NIH HHS
Comments/Corrections

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