Document Detail

Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women.
MedLine Citation:
PMID:  15640479     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The incidence of cardiovascular disease increases after menopause, possibly because of the decline in estrogen. Soy protein, a rich source of estrogen-like isoflavones, is hypothesized to improve vascular function. OBJECTIVE: The objective of this study was to investigate whether supplementation with soy protein, a rich source of estrogen-like isoflavones, improves vascular function. DESIGN: We performed a 12-mo double-blind randomized trial to compare the effects of soy protein containing 99 mg isoflavones/d (aglycone weights) with those of milk protein (placebo) on blood pressure and endothelial function in 202 postmenopausal women aged 60-75 y. RESULTS: Changes in endothelial function during the intervention were not significantly different between the soy and the placebo groups. After the intervention, systolic blood pressure increased in the soy group significantly more than it did in the placebo group; the difference in change was 4.3 mm Hg (95% CI: 0.3, 8.4 mm Hg; P = 0.04) for systolic blood pressure, but only 2.0 mm Hg (95% CI: -0.74, 4.71 mm Hg; P = 0.15) for diastolic blood pressure. In the soy group only, systolic and diastolic blood pressure decreased and endothelial function improved in the equol producers, whereas systolic and diastolic blood pressure increased and endothelial function deteriorated in the equol nonproducers. CONCLUSIONS: The results of this trial do not support the hypothesis that soy protein containing isoflavones have beneficial effects on vascular function in older postmenopausal women. Whether certain subgroups of women (eg, equol producers) do benefit from the intervention remains to be elucidated.
Sanne Kreijkamp-Kaspers; Linda Kok; Michiel L Bots; Diederick E Grobbee; Johanna W Lampe; Yvonne T van der Schouw
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  81     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-10     Completed Date:  2005-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  AIM; IM    
The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands.
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MeSH Terms
Blood Pressure / drug effects*
Double-Blind Method
Endothelium, Vascular / drug effects*
Isoflavones / pharmacology*
Middle Aged
Milk Proteins / pharmacology*
Soybean Proteins / pharmacology*
Reg. No./Substance:
0/Isoflavones; 0/Milk Proteins; 0/Soybean Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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