Document Detail

Randomized controlled trial: effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization.
MedLine Citation:
PMID:  20646688     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the influence of "true" versus "sham" acupuncture on pregnancy rates (PRs) in women undergoing IVF.
DESIGN: Randomized controlled trial, double-blinded with independent observer.
SETTING: Academic infertility clinic.
PATIENT(S): One hundred sixty patients <38 years old undergoing IVF with or without intracytoplasmic sperm injection.
INTERVENTION(S): Subjects were randomly allocated to the true or sham group and underwent acupuncture 25 minutes before and after ET. Subjects completed a McGill Pain Questionnaire regarding their clinical symptoms during ET.
MAIN OUTCOME MEASURE(S): Clinical PR and clinical symptoms during ET.
RESULT(S): While the overall clinical PR was 51.25%, there was no significant difference between the arms of the study (true = 45.3% vs. sham = 52.7%); 33.1% of the patients had ultrasound-documented singleton pregnancy, and 15% of patients had twin gestations, while one patient in the true arm had a triplet gestation. There were significant differences in the subjective, affective, and total pain experience between both arms. The subjects in the true arm described their acupuncture session as being more "tiring" and "fearful" and experienced more "achiness" compared with their sham counterparts.
CONCLUSION(S): There was no statistically significant difference in the clinical or chemical PRs between both groups. Patients undergoing true acupuncture had differing sensory experiences compared with patients in the sham arm. There were no significant adverse effects observed during the study, suggesting that acupuncture is safe for women undergoing ET.
Irene Moy; Magdy P Milad; Randall Barnes; Edmond Confino; Ralph R Kazer; Xingqi Zhang
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-20
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  2011-02-28     Revised Date:  2011-07-11    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  583-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA.
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MeSH Terms
Acupuncture Therapy* / psychology
Cell Count
Double-Blind Method
Fertilization in Vitro* / psychology
Infertility / psychology,  therapy*
Oocyte Retrieval
Oocytes / cytology
Pregnancy Rate*
Comment In:
Fertil Steril. 2011 Jun;95(7):e33; author reply e34   [PMID:  21457965 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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