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Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome.
MedLine Citation:
PMID:  21518135     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  To compare the efficacy of 1000 mg and 1700 mg of metformin on ovulation induction in polycystic ovary syndrome (PCOS) women. Material and Methods:  A randomized controlled trial was conducted at Ramathibodi Hospital, Mahidol University, Bangkok, Thailand of 60 PCOS women diagnosed by Rotterdam criteria. Group A (30 women) and B (30 women) received 1000 mg and 1700 mg/day of metformin, respectively. Clomiphen citrate 50-150 mg per day for 5 days was added, if no dominant follicle developed. The main outcome measures were ovulation and pregnancy rates, fasting insulin (FI), testosterone (T), androstenedione (ADD) and DHEAS before and 4 weeks after metformin. Results:  The ovulation rate did not differ between the groups (84.8% vs 87.7% between groups A and B, P = NS). Most of the women developed one follicle (91% in group A and 88.2% in group B, P = NS). The pregnancy rate in group A (46.4% per woman and 12.4% per ovulatory cycle) did not differ from that in group B (51.9% per woman and 13.2% per ovulatory cycle, P = NS). With regard to dosages, the ovulation rate in PCOS women without insulin resistance (IR) was significantly higher than those with IR. FI, T and ADD were significantly decreased after 4 weeks of metformin in both groups. Conclusion:  1000 mg of metformin had as high efficacy as 1700 mg on induction of ovulation and pregnancy in PCOS women.
Authors:
Sawaek Weerakiet; Areepan Sophonsritsuk; Srithean Lertvikool; Chonthicha Satirapot; Supatra Leelaphiwat; Rattiya Jultanmas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-26
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  -     ISSN:  1341-8076     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.
Affiliation:
Departments of Obstetrics and Gynecology Pathology Nursing, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
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