Document Detail

Randomized controlled trial of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates on body weight and blood lipids: the CARMEN study. The Carbohydrate Ratio Management in European National diets.
MedLine Citation:
PMID:  11093293     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the long-term effects of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates.
DESIGN: Randomized controlled multicentre trial (CARMEN), in which subjects were allocated for 6 months either to a seasonal control group (no intervention) or to one of three experimental groups: a control diet group (dietary intervention typical of the average national intake); a low-fat high simple carbohydrate group; or a low-fat high complex carbohydrate group.
SUBJECTS: Three hundred and ninety eight moderately obese adults.
MEASUREMENTS: The change in body weight was the primary outcome; changes in body composition and blood lipids were secondary outcomes.
RESULTS: Body weight loss in the low-fat high simple carbohydrate and low-fat high complex carbohydrate groups was 0.9 kg (P < 0.05) and 1.8 kg (P < 0.001), while the control diet and seasonal control groups gained weight (0.8 and 0.1 kg, NS). Fat mass changed by -1.3kg (P< 0.01), -1.8kg (P< 0.001) and +0.6kg (NS) in the low-fat high simple carbohydrate, low-fat high complex carbohydrate and control diet groups, respectively. Changes in blood lipids did not differ significantly between the dietary treatment groups.
CONCLUSION: Our findings suggest that reduction of fat intake results in a modest but significant reduction in body weight and body fatness. The concomitant increase in either simple or complex carbohydrates did not indicate significant differences in weight change. No adverse effects on blood lipids were observed. These findings underline the importance of this dietary change and its potential impact on the public health implications of obesity.
W H Saris; A Astrup; A M Prentice; H J Zunft; X Formiguera; W P Verboeket-van de Venne; A Raben; S D Poppitt; B Seppelt; S Johnston; T H Vasilaras; G F Keogh
Related Documents :
821033 - Sensitivity to carbohydrate in a patient with familial intermittent lactic acidosis and...
17823443 - Fatty acid desaturase regulation in adipose tissue by dietary composition is independen...
8276213 - Effects of dietary menhaden oil on mucosal adaptation after small bowel resection in rats.
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  24     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-29     Completed Date:  2001-05-03     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1310-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Composition
Body Weight / drug effects*
Dietary Carbohydrates / administration & dosage*,  pharmacology
Dietary Fats / administration & dosage*,  pharmacology
Energy Intake
Intervention Studies
Lipids / blood*
Middle Aged
Obesity / diet therapy*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Different patterns of brisk walking are equally effective in decreasing postprandial lipaemia.
Next Document:  Parental eating attitudes and the development of obesity in children. The Framingham Children's Stud...