Document Detail

Randomized, controlled trial of bupivacaine injection to decrease pain after laparoscopic cholecystectomy.
MedLine Citation:
PMID:  10459328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine if intraoperative instillation of bupivacaine would decrease early postoperative pain after laparoscopic cholecystectomy, if the patients would consequently require less narcotic postoperatively and if such patients would elect to be discharged on the day of operation if given the choice.
DESIGN: Double-blind, randomized, controlled trial.
SETTING: A tertiary care hospital in Hamilton, Ont.
PATIENTS: Fifty patients underwent laparoscopic cholecystectomy. Day-surgery patients had the choice of staying overnight for discharge the following day. They were compared with a control group of 47 patients who had laparoscopic cholecystectomy but did not receive bupivacaine.
INTERVENTION: Instillation of 20 mL of 0.5% bupivacaine with epinephrine into laparoscopic cholecystectomy port sites intraoperatively before closure.
MAIN OUTCOME MEASURES: Visual analogue scale (VAS) pain scores assessed 4 times postoperatively, the choice of patients to leave hospital the same day or to remain in the hospital overnight; the level of postoperative narcotic usage.
MAIN RESULTS: Mean VAS pain scores (range 0 [no pain] to 5 [severe pain]) at less than 2 hours and at 6 hours after surgery were 2.9 and 2.9, respectively, in the bupivacaine group compared with 4.5 and 4.0, respectively, in the control group (p = 0.001 and 0.025). VAS scores at 10 hours postoperatively and the next morning did not differ between the groups. More patients in the bupivacaine group elected to go home on the day of surgery (p = 0.034). Narcotic usage was not significantly different.
CONCLUSION: Instillation of bupivacaine into port sites should be standard practice for elective laparoscopic cholecystectomy.
D Dath; A E Park
Related Documents :
21091528 - Clinical and radiographic outcomes following non-surgical therapy of periodontal infrab...
1389818 - Comparison of the maternal and fetal effects associated with intermittent or continuous...
1925848 - A model for investigating the systemic effects of adrenaline in dental local anaestheti...
20572408 - Patient outcomes comparing crna-administered peripheral nerve blocks and general anesth...
25017948 - Wound healing properties of quince seed mucilage: in vivo evaluation in rabbit full-th...
19760948 - Analysis of bclc treatment indications. have bclc modified our choice of treatment in h...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of surgery. Journal canadien de chirurgie     Volume:  42     ISSN:  0008-428X     ISO Abbreviation:  Can J Surg     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-09     Completed Date:  1999-09-09     Revised Date:  2013-11-01    
Medline Journal Info:
Nlm Unique ID:  0372715     Medline TA:  Can J Surg     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  284-8     Citation Subset:  IM    
Department of Surgery, St. Joseph's Hospital, McMaster University, Hamilton, Ont.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics, Local* / administration & dosage
Bupivacaine* / administration & dosage
Cholecystectomy, Laparoscopic*
Double-Blind Method
Middle Aged
Pain Measurement
Pain, Postoperative / prevention & control*
Treatment Outcome
Reg. No./Substance:
0/Anesthetics, Local; 2180-92-9/Bupivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Treatment of osteonecrosis of the femoral head by free vascularized fibular grafting: an analysis of...
Next Document:  Sickle cell disease of the spine in children.