| Randomized controlled trial of DOTS versus conventional regime for treatment of ileocecal and colonic tuberculosis. | |
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MedLine Citation:
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PMID: 18541933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is limited information regarding the efficacy of 'directly observed treatment short course' (DOTS) in the treatment of intestinal tuberculosis. We randomized patients with ileocecal or colonic tuberculosis to receive daily tuberculosis chemotherapy (Group A) or DOTS (Group B). Patients received isoniazid, rifampicin, pyrazinamide and ethambutol daily for two months in group A and thrice weekly for 2 months in group B, followed by isoniazid and rifampicin daily for 7 months in group A and thrice weekly for 4 months in group B. Patients were followed up at 2 and 4 weeks and monthly thereafter until the end of treatment. Follow up colonoscopy was done at 2 and 6 months after starting treatment. The improvement in clinical symptoms was not different between Groups A (24) and B (23) at 2 and 6 months. Mean increase in weight was 5.1 (0.5) Kg and 5.7 (0.6) Kg at 2 months and 7.1 (1.7) Kg and 6.9 (1.9) Kg at 6 months in Group A and B, respectively. Complete healing of ulceration was noted in 75% of Group A patients and 79% of Group B patients at 2 months and in all patients in both groups at 6 months. We conclude that DOTS and daily chemotherapy are equally effective for treating ileocecal and colonic tuberculosis. |
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Authors:
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Jose Tony; K Sunilkumar; Varghese Thomas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology Volume: 27 ISSN: 0254-8860 ISO Abbreviation: Indian J Gastroenterol Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2008-06-10 Completed Date: 2008-09-25 Revised Date: 2010-04-12 |
Medline Journal Info:
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Nlm Unique ID: 8409436 Medline TA: Indian J Gastroenterol Country: India |
Other Details:
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Languages: eng Pagination: 19-21 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Calicut Medical College, Kerala, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antitubercular Agents
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administration & dosage Cecal Diseases / drug therapy* Colonic Diseases / drug therapy* Directly Observed Therapy* Humans Ileal Diseases / drug therapy* Treatment Outcome Tuberculosis, Gastrointestinal / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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