Document Detail

Randomized controlled trial of DOTS versus conventional regime for treatment of ileocecal and colonic tuberculosis.
MedLine Citation:
PMID:  18541933     Owner:  NLM     Status:  MEDLINE    
There is limited information regarding the efficacy of 'directly observed treatment short course' (DOTS) in the treatment of intestinal tuberculosis. We randomized patients with ileocecal or colonic tuberculosis to receive daily tuberculosis chemotherapy (Group A) or DOTS (Group B). Patients received isoniazid, rifampicin, pyrazinamide and ethambutol daily for two months in group A and thrice weekly for 2 months in group B, followed by isoniazid and rifampicin daily for 7 months in group A and thrice weekly for 4 months in group B. Patients were followed up at 2 and 4 weeks and monthly thereafter until the end of treatment. Follow up colonoscopy was done at 2 and 6 months after starting treatment. The improvement in clinical symptoms was not different between Groups A (24) and B (23) at 2 and 6 months. Mean increase in weight was 5.1 (0.5) Kg and 5.7 (0.6) Kg at 2 months and 7.1 (1.7) Kg and 6.9 (1.9) Kg at 6 months in Group A and B, respectively. Complete healing of ulceration was noted in 75% of Group A patients and 79% of Group B patients at 2 months and in all patients in both groups at 6 months. We conclude that DOTS and daily chemotherapy are equally effective for treating ileocecal and colonic tuberculosis.
Jose Tony; K Sunilkumar; Varghese Thomas
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  27     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-09-25     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  19-21     Citation Subset:  IM    
Department of Gastroenterology, Calicut Medical College, Kerala, India.
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MeSH Terms
Antitubercular Agents / administration & dosage
Cecal Diseases / drug therapy*
Colonic Diseases / drug therapy*
Directly Observed Therapy*
Ileal Diseases / drug therapy*
Treatment Outcome
Tuberculosis, Gastrointestinal / drug therapy*
Reg. No./Substance:
0/Antitubercular Agents

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