| Randomized, controlled study evaluating effects of branched chain amino acids and alpha-ketoisocaproate on protein metabolism after surgery. | |
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MedLine Citation:
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PMID: 1555086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of nutritional supplementation with branched chain amino acids or the ketoacid alpha-ketoisocaproate on protein metabolism after surgery was studied in 24 patients with gastrointestinal cancer. They were randomized to receive one of three nutritional regimens. All patients received a balanced amino acid solution and group 1 (n = 8) received no further supplements, group 2 (n = 8) received supplementation with alpha-ketoisocaproate (17 g day-1) and group 3 (n = 8) received a branched chain solution including leucine, isoleucine and valine, corresponding to 3.3 g nitrogen day-1. Plasma albumin, prealbumin, fibronectin and serum urea concentrations, nitrogen balance and 3-methylhistidine release from the leg and its excretion in the urine were measured. Albumin and prealbumin concentrations fell after surgery in all groups, and fibronectin levels fell in group 2 (P less than 0.001). In group 2 there was also a significant increase in serum urea concentration after operation (P less than 0.05). Cumulative nitrogen balance after 3 days was -5.6 g (group 1), -3.8 g (group 2) and -1.7 g (group 3). The release of 3-methylhistidine (nmol 100 g-1 min-1) from the leg after operation, following an overnight fast, was -0.42 (group 1), -0.51 (group 2) and -0.66 (group 3). During infusion the release was -0.56, -0.99 and -0.81, respectively. A balanced amino acid solution with an adequate energy supply has an optimal nitrogen-sparing effect. Branched chain amino acids or alpha-ketoisocaproate did not improve nitrogen balance or reduce protein degradation. |
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Authors:
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S Sandstedt; L Jorfeldt; J Larsson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of surgery Volume: 79 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-05-04 Completed Date: 1992-05-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 217-20 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesiology, University Hospital, Linköping, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Branched-Chain
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therapeutic use* Caproates / therapeutic use* Female Gastrointestinal Neoplasms / surgery* Humans Keto Acids / therapeutic use* Male Methylhistidines / metabolism Middle Aged Nitrogen / metabolism Parenteral Nutrition, Total Postoperative Period Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Branched-Chain; 0/Caproates; 0/Keto Acids; 0/Methylhistidines; 0/Proteins; 368-16-1/3-methylhistidine; 7727-37-9/Nitrogen; 816-66-0/alpha-ketoisocaproic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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