| Randomized controlled study of digestive enzyme activity following trophic feeding. | |
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MedLine Citation:
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PMID: 12022301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A randomized, controlled, prospective study of 80 preterm infants of birthweight less than 1750 g requiring ventilatory support was performed. While ventilatory support was required group TF (39 infants) received trophic feeding (0.5-1 ml h(-1)) along with parenteral nutrition, whereas group C (41 infants) received parenteral nutrition alone. When ventilatory support was no longer required milk feeds were started in group C and then increased in both groups until full milk feeds were established. The ratio of lactase to sucrase activity (L:S ratio) was measured in aspirated proximal intestinal fluid on 3 occasions: immediately after ventilatory support was withdrawn (T0), 7 days later (T7) and 14 days later (T14). On the same 3 occasions faecal chymotrypsin activity was measured. The mean difference (95% confidence interval) L:S ratio was significantly higher in group TF at both T0 and T14, 1.8 (0.03, 3.57) and 0.78 (0.2, 1.35) U l(-1), respectively. There was no significant difference in faecal chymotrypsin concentration. CONCLUSION: Trophic feeding alters relative intestinal disaccharidase activity, probably by inducing lactase production, but has no effect on pancreatic chymotrypsin activity. |
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Authors:
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R J McClure; S J Newell |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 91 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-05-22 Completed Date: 2002-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 292-6 Citation Subset: IM |
Affiliation:
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Regional Neonatal Intensive Care Unit, St James's University Hospital, Leeds, UK. rob.mcclure@addenbrookes.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chymotrypsin
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analysis,
metabolism* Confidence Intervals Digestive System / enzymology* Enteral Nutrition / methods* Feces / chemistry Female Follow-Up Studies Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature / growth & development* Lactase Male Pancreas / enzymology* Parenteral Nutrition / methods* Probability Prospective Studies Respiration, Artificial Statistics, Nonparametric Sucrase / analysis, metabolism beta-Galactosidase / analysis, metabolism |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.108/Lactase; EC 3.2.1.23/beta-Galactosidase; EC 3.2.1.48/Sucrase; EC 3.4.21.1/Chymotrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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