Document Detail


Randomized controlled field trial to assess efficacy of a Moraxella bovis pilin-cytotoxin-Moraxella bovoculi cytotoxin subunit vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis.
MedLine Citation:
PMID:  23013196     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective-To evaluate efficacy of a recombinant Moraxella bovis pilin-cytotoxin-Moraxella bovoculi cytotoxin subunit vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis (IBK). Animals-107 beef steers. Procedures-2 groups of calves were inoculated SC with an immunostimulating complex (ISCOM) matrix adjuvant (control group; n = 54) or a recombinant M bovis pilin-cytotoxin-M bovoculi cytotoxin subunit antigen with the ISCOM matrix adjuvant (vaccine group; 53); calves received booster injections 21 days later. Calves were examined once weekly for 16 weeks. Investigators and herd managers were not aware of the inoculum administered to each calf throughout the trial. Primary outcome of interest was the cumulative proportion of calves that developed IBK. Serum samples were obtained before inoculation (day 0) and on days 42 and 112. Serum hemolysin-neutralizing titers against native M bovis and M bovoculi cytotoxin were determined. Results-No difference was detected between groups for the cumulative proportion of calves that developed IBK at weeks 8 and 16 after inoculation. Non-IBK-affected calves in the vaccine group had a significantly higher fold change in serum hemolysin-neutralizing titer against native M bovoculi cytotoxin from day 0 to 42 compared to control calves. Conclusions and Clinical Relevance-The M bovis pilin-cytotoxin-M bovoculi cytotoxin subunit vaccine with the ISCOM matrix adjuvant was not effective at preventing naturally occurring IBK. It is likely that the incorporation of additional protective antigens in a recombinant Moraxella spp subunit vaccine will be required to yield a product that can be used for effective immunization of cattle against IBK.
Authors:
John A Angelos; Khaled G Gohary; Louise M Ball; John F Hess
Related Documents :
24887426 - Induction of neutralizing antibody response against four dengue viruses in mice by intr...
23698486 - Prospective safety monitoring of haemophilus influenzae type b and heptavalent pneumoco...
23599316 - Efficacy, immunogenicity, and safety of two doses of a tetravalent rotavirus vaccine rr...
25424916 - Human vaccines & immunotherapeutics.
21310786 - Gapa+ mycoplasma gallisepticum ts-11 has improved vaccine characteristics.
6129376 - Rational strategy for rubella vaccination.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  73     ISSN:  1943-5681     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1670-5     Citation Subset:  IM    
Affiliation:
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of sterilization with hydrogen peroxide gas plasma, ethylene oxide, and steam on bioadhesive...
Next Document:  Grover's disease secondarily infected with herpes simplex virus and Staphylococcus aureus: Case repo...