Document Detail

Randomized, controlled, bilateral (split-face) comparison trial of the tolerability and patient preference of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.
MedLine Citation:
PMID:  11845944     Owner:  NLM     Status:  MEDLINE    
Poor patient compliance is one of the main reasons for treatment failure in acne. Our objective was to evaluate the tolerability and patient preference of adapalene gel 0.1% compared with tretinoin microsphere gel 0.1% using a randomized, controlled, investigator-masked, bilateral (split-face), 4-week comparative study of the 2 products when applied once daily in 40 patients. We found that adapalene produced less stinging/burning than tretinoin at weeks 1 and 4 and, overall, more patients felt more skin irritation on the side of the face treated with tretinoin than on the side treated with adapalene (P<.05). At week 4, a significantly greater number of patients preferred adapalene gel 0.1% to tretinoin microsphere gel 0.1% (72.5% vs 27.5%, respectively, P<.01).
N Egan; M C Loesche; M M Baker
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cutis     Volume:  68     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-08-12     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
International Research Services, Inc, Rockland, Maine, USA.
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MeSH Terms
Acne Vulgaris / drug therapy*
Administration, Topical
Anti-Inflammatory Agents, Non-Steroidal / adverse effects,  therapeutic use*
Dermatologic Agents / adverse effects,  therapeutic use*
Keratolytic Agents / adverse effects,  therapeutic use
Naphthalenes / adverse effects,  therapeutic use*
Patient Satisfaction
Treatment Outcome
Tretinoin / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Dermatologic Agents; 0/Keratolytic Agents; 0/Naphthalenes; 1L4806J2QF/adapalene; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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