| Randomized, controlled, bilateral (split-face) comparison trial of the tolerability and patient preference of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris. | |
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MedLine Citation:
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PMID: 11845944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poor patient compliance is one of the main reasons for treatment failure in acne. Our objective was to evaluate the tolerability and patient preference of adapalene gel 0.1% compared with tretinoin microsphere gel 0.1% using a randomized, controlled, investigator-masked, bilateral (split-face), 4-week comparative study of the 2 products when applied once daily in 40 patients. We found that adapalene produced less stinging/burning than tretinoin at weeks 1 and 4 and, overall, more patients felt more skin irritation on the side of the face treated with tretinoin than on the side treated with adapalene (P<.05). At week 4, a significantly greater number of patients preferred adapalene gel 0.1% to tretinoin microsphere gel 0.1% (72.5% vs 27.5%, respectively, P<.01). |
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Authors:
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N Egan; M C Loesche; M M Baker |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cutis; cutaneous medicine for the practitioner Volume: 68 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2002-02-15 Completed Date: 2002-08-12 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006440 Medline TA: Cutis Country: United States |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: IM |
Affiliation:
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International Research Services, Inc, Rockland, Maine, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy* Administration, Topical Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal / adverse effects, therapeutic use* Dermatologic Agents / adverse effects, therapeutic use* Female Humans Keratolytic Agents / adverse effects, therapeutic use Male Naphthalenes / adverse effects, therapeutic use* Patient Satisfaction Treatment Outcome Tretinoin / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Dermatologic Agents; 0/Keratolytic Agents; 0/Naphthalenes; 106685-40-9/adapalene; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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