| Randomized comparison of topical betamethasone valerate foam, intralesional triamcinolone acetonide and tacrolimus ointment in management of localized alopecia areata. | |
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MedLine Citation:
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PMID: 21769231 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Alopecia areata (AA) is a common, non-scarring, patchy loss of hair at scalp and elsewhere. Its pathogenesis is uncertain; however, auto-immunity has been exemplified in various studies. Familial incidence of AA is 10-42%, but in monozygotic twins is 50%. Local steroids (topical / intra-lesional) are very effective in treatment of localized AA. AIM: To compare hair regrowth and side effects of topical betamethasone valerate foam, intralesional triamcinolone acetonide and tacrolimus ointment in management of localized AA. MATERIALS AND METHODS: 105 patients of localized AA were initially registered but 27 were drop out. So, 78 patients allocated at random in group A (28), B (25) and C (25) were prescribed topical betamethasone valerate foam (0.1%) twice daily, intralesional triamcinolone acetonide (10mg/ml) every 3 weeks and tacrolimus ointment (0.1%) twice daily, respectively, for 12 weeks. They were followed for next12 weeks. Hair re-growth was calculated using "HRG Scale"; scale I- (0-25%), S II-(26-50%), S III - (51-75%) and S IV- (75-100%). RESULTS: Hair re-growth started by 3 weeks in group B (Scale I: P<0.03), turned satisfactory at 6 weeks in group A and B (Scale I: P<0.005, Scale IV: P<0.001)), good at 9 weeks (Scale I: P<0.0005, Scale IV: P<0.00015), and better by 12 weeks of treatment (Scale I: P<0.000021, Scale IV: P<0.000009) in both A and B groups. At the end of 12 weeks follow-up hair re-growth (>75%, HRG IV) was the best in group B (15 of 25, 60%), followed by A (15 of 28, 53.6%) and lastly group-C (Nil of 25, 0%) patients. Few patients reported mild pain and atrophy at injection sites, pruritus and burning with betamethasone valerate foam and tacrolimus. CONCLUSION: Intralesional triamcinolone acetonide is the best, betamethasone valerate foam is better than tacrolimus in management of localized AA. |
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Authors:
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Cm Kuldeep; Himanshu Singhal; Ashok Kumar Khare; Asit Mittal; Lalit K Gupta; Anubhav Garg |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of trichology Volume: 3 ISSN: 0974-9241 ISO Abbreviation: Int J Trichology Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-07-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101534370 Medline TA: Int J Trichology Country: India |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: - |
Affiliation:
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Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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