Document Detail

Randomized comparison of the influence of dietary management and/or physical exercise on ovarian function and metabolic parameters in overweight women with polycystic ovary syndrome.
MedLine Citation:
PMID:  21962963     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the influence of dietary management and/or physical exercise on ovarian function and metabolic variables in women with polycystic ovary syndrome (PCOS).
DESIGN: Randomized 4-month trial with three interventions and a long-term follow-up.
SETTING: Women's health clinical research unit at a university hospital.
PATIENT(S): Fifty-seven overweight/obese women with PCOS.
INTERVENTION(S): Dietary management, physical exercise, or both, using programs individually adapted and supervised by a dietician and/or a physical therapist.
MAIN OUTCOME MEASURE(S): Ovarian function, endocrinologic, and metabolic status and body composition.
RESULT(S): On average, body mass index was reduced 6% by the dietary management, 3% by the exercise, and 5% by the combined interventions. Lower body fat and lean body mass were significantly decreased in the dietary groups, whereas upper body fat was lowered and lean body mass maintained by exercise alone. The menstrual pattern was significantly improved in 69% and ovulation confirmed in 34% of the patients, with no differences among the groups. The strongest predictor of resumed ovulation was a high serum level of insulin-like growth factor-binding protein 1 after the intervention. Follow-up of one-half of the patients for a median of 2.8 years revealed sustained weight reduction and improvement in menstrual pattern.
CONCLUSION(S): Dietary management and exercise, alone or in combination, are equally effective in improving reproductive function in overweight/obese women with PCOS. The underlying mechanisms appear to involve enhanced insulin sensitivity. Supportive individualized programs for lifestyle change could exert long-term beneficial effects.
Åsa Nybacka; Kjell Carlström; Agneta Ståhle; Sven Nyrén; Per Martin Hellström; Angelica Lindén Hirschberg
Related Documents :
2904883 - Effect of calcium channel blockade and beta-adrenoceptor blockade on short graded and s...
20620233 - Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestr...
12166883 - Promoting physical activity in a socially and economically deprived community: a 12 mon...
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-09-29
Journal Detail:
Title:  Fertility and sterility     Volume:  96     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-01     Completed Date:  2012-01-23     Revised Date:  2012-03-06    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1508-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Combined Modality Therapy
Diet Therapy*
Exercise / physiology*
Exercise Therapy*
Follow-Up Studies
Ovary / physiology*
Overweight / complications,  metabolism,  physiopathology,  therapy*
Polycystic Ovary Syndrome / complications,  metabolism,  physiopathology,  therapy*
Young Adult
Comment In:
Fertil Steril. 2012 Feb;97(2):e5; author reply e6   [PMID:  22200176 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Magnetic resonance imaging visualization of a vaginal septum.
Next Document:  Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate wi...