| Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic. | |
| | |
MedLine Citation:
|
PMID: 15486837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Recent clinical trials in the Lao People's Democratic Republic have demonstrated that chloroquine and sulfadoxine-pyrimethamine, which are national malaria treatment policy, are no longer effective in the treatment of uncomplicated Plasmodium falciparum malaria. METHODS: A randomized comparison of 3 oral antimalarial combinations--chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine--with 42-day follow-up period, was conducted among 330 patients with acute uncomplicated falciparum malaria in southern Laos. RESULTS: The 42-day cure rates, as determined by intention-to-treat analysis and adjusted for reinfection, were 100%, 97%, and 93% for the groups receiving artesunate plus mefloquine, artemether-lumefantrine, and chloroquine plus sulfadoxine-pyrimethamine, respectively. Of 8 patients receiving chloroquine plus sulfadoxine-pyrimethamine who experienced treatment failure, 6 had early treatment failure. The mean parasite clearance time was significantly longer in patients treated with chloroquine plus sulfadoxine-pyrimethamine (2.9 days; 95% confidence interval [CI], 2.8-3.0 days) than in those treated with artesunate plus mefloquine (2.07 days; 95% CI, 2.0-2.1 days; P<.001) and artemether-lumefantrine (2.08 days; 95% CI, 2.0-2.1 days; P<.001). Cure rates with artemether-lumefantrine were high despite low mean daily dietary fat intake (13.8 g; 95% CI, 12.5-15.1 g) and day 7 plasma lumefantrine concentrations (0.47 mu g/mL; 95% CI, 0.38-0.56 mu g/mL). CONCLUSION: Oral artesunate plus mefloquine and artemether-lumefantrine are highly effective for the treatment of uncomplicated falciparum malaria in Laos. |
| | |
Authors:
|
Mayfong Mayxay; Maniphone Khanthavong; Niklas Lindegårdh; Siamphay Keola; Marion Barends; Tiengkham Pongvongsa; Ratsuda Yapom; Anna Annerberg; Samlane Phompida; Rattanaxay Phetsouvanh; Nicholas J White; Paul N Newton |
Related Documents
:
|
21526697 - Non-invasive ventilation: established and expanding roles. 23055847 - Lessons from a successful implementation of a computerized provider order entry system. 23509617 - Interest of monitoring diaphragmatic electrical activity in the pediatric intensive car... 23331347 - Making the case for primary care and mandated suicide prevention education. 21761947 - Economic considerations for the treatment of opioid and alcohol dependence: a managed c... 2122797 - Caring knowledge and informed moral passion. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2004-09-27 |
Journal Detail:
|
Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 39 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2004 Oct |
Date Detail:
|
Created Date: 2004-10-15 Completed Date: 2006-06-01 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 1139-47 Citation Subset: IM |
Affiliation:
|
Wellcome Trust-Mahosot Hospital, Oxford Tropical Medicine Research Collaboration, Vientiane, Lao PDR. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Antimalarials / therapeutic use* Artemisinins / administration & dosage, therapeutic use* Child Child, Preschool Chloroquine / administration & dosage, therapeutic use* Drug Combinations Drug Therapy, Combination Ethanolamines / therapeutic use Female Fluorenes / therapeutic use Humans Infant Laos Malaria, Falciparum / drug therapy* Male Mefloquine / administration & dosage, therapeutic use* Pyrimethamine / administration & dosage, therapeutic use* Sesquiterpenes / administration & dosage, therapeutic use* Sulfadoxine / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Antimalarials; 0/Artemisinins; 0/Drug Combinations; 0/Ethanolamines; 0/Fluorenes; 0/Sesquiterpenes; 0/artemether; 2447-57-6/Sulfadoxine; 37338-39-9/sulfadoxine-pyrimethamine; 53230-10-7/Mefloquine; 54-05-7/Chloroquine; 58-14-0/Pyrimethamine; 82186-77-4/lumefantrine; 83507-69-1/artesunate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multicenter study of a rapid molecular-based assay for the diagnosis of group B Streptococcus coloni...
Next Document: An outbreak of conjunctivitis due to a novel unencapsulated Streptococcus pneumoniae among military ...