Document Detail

Randomized comparison between intravaginal misoprostol and dinoprostone for cervical ripening and induction of labor.
MedLine Citation:
PMID:  10486474     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to evaluate the efficacy and safety of intravaginal misoprostol and dinoprostone for labor induction. STUDY DESIGN: One hundred eighty-nine women with singleton term pregnancies and unfavorable cervices were randomly assigned to receive intravaginal misoprostol or dinoprostone. The outcome variables were change in Bishop score, time from application to active phase of labor and delivery, fetal and maternal morbidity, and the incidence of cesarean deliveries. RESULTS: The interval from application of the initial dose to the beginning of the active phase of labor was 9.8 +/- 5.8 and 14.2 +/- 10.2 hours (P <.01), and the interval from initial dose to delivery was 15.3 +/- 9.8 and 19.1 +/- 13.2 hours (P =.027) for the misoprostol and dinoprostone groups, respectively. There were no significant differences in Bishop score change, cesarean delivery rate, and the incidence of tachysystole, hypersystole, and hyperstimulation. No maternal and neonatal adverse effects were noted. CONCLUSION: Intravaginal misoprostol is more effective than intravaginal dinoprostone for labor induction in low-risk patients at term with unfavorable cervices.
F Nunes; R Rodrigues; M Meirinho
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  181     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-07     Completed Date:  1999-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  626-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Hospital Garcia de Orta, 2800 Almada, Portugal.
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MeSH Terms
Administration, Intravaginal
Cervix Uteri / physiology*
Cesarean Section
Dinoprostone / administration & dosage*,  therapeutic use
Heart Rate, Fetal
Labor, Induced*
Misoprostol / administration & dosage*,  therapeutic use
Oxytocics / administration & dosage*,  therapeutic use
Time Factors
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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