| Randomized clinical trials for colorectal cancer peritoneal surface malignancy. | |
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MedLine Citation:
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PMID: 23021723 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Upwards of 40% of patient with colorectal cancer develop peritoneal carcinomatosis (CRCPC). Of the 2500 patients reported in the literature, 1000 underwent cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC), resulting in median survival of 22 to 63 months. However, level I data from prospective randomized trials are limited. Further trials are indicated to identify peritoneal carcinomatosis in at-risk patients early in the natural history of the disease and confirm the efficacy of multimodality therapy (CRS/HIPEC/systemic therapy) in those with CRCPC amenable to CRS in the modern era of novel targeted and cytotoxic systemic therapy. |
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Authors:
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Itzhak Avital; Björn L D M Brücher; Aviram Nissan; Alexander Stojadinovic |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgical oncology clinics of North America Volume: 21 ISSN: 1558-5042 ISO Abbreviation: Surg. Oncol. Clin. N. Am. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211789 Medline TA: Surg Oncol Clin N Am Country: United States |
Other Details:
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Languages: eng Pagination: 665-88 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Bon Secours Cancer Institute, Peritoneal Surface Malignancies Center of Excellence, 5855 Bremo Street, Suite 405, Richmond, VA 23226, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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