Document Detail


Randomized clinical trials for colorectal cancer peritoneal surface malignancy.
MedLine Citation:
PMID:  23021723     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Upwards of 40% of patient with colorectal cancer develop peritoneal carcinomatosis (CRCPC). Of the 2500 patients reported in the literature, 1000 underwent cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC), resulting in median survival of 22 to 63 months. However, level I data from prospective randomized trials are limited. Further trials are indicated to identify peritoneal carcinomatosis in at-risk patients early in the natural history of the disease and confirm the efficacy of multimodality therapy (CRS/HIPEC/systemic therapy) in those with CRCPC amenable to CRS in the modern era of novel targeted and cytotoxic systemic therapy.
Authors:
Itzhak Avital; Björn L D M Brücher; Aviram Nissan; Alexander Stojadinovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical oncology clinics of North America     Volume:  21     ISSN:  1558-5042     ISO Abbreviation:  Surg. Oncol. Clin. N. Am.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211789     Medline TA:  Surg Oncol Clin N Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  665-88     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Bon Secours Cancer Institute, Peritoneal Surface Malignancies Center of Excellence, 5855 Bremo Street, Suite 405, Richmond, VA 23226, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
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