Document Detail

Randomized clinical trial of transabdominal versus transcervical chorionic villus sampling methods.
MedLine Citation:
PMID:  1896416     Owner:  NLM     Status:  MEDLINE    
The relative advantages and disadvantages of transabdominal (TA) and transcervical (TC) chorionic villus sampling (CVS) in terms of fetal risks and efficacy were evaluated in a clinical trial conducted on 1194 women randomized at 7-12 weeks' gestation. The results of the study indicate that, if any, the relative risk of fetal loss following either procedure is less than double that of the alternative technique when performed by a skilled operator. Overall, the fetal loss rate (spontaneous abortions following randomization, terminations of pregnancy, and perinatal deaths) is 16.5 and 15.5 per cent, respectively, among women allocated to TA- and TC-CVS. The two procedures are equally effective, although TA-CVS is associated with a significantly lower rate of repeat device insertions; on the other hand, a higher weight of chorionic tissue is obtained, on average, with TC-CVS. Bleeding is more common following TC-CVS, while peritoneal reaction developed only after TA-CVS. No diagnostic problems specifically related to one sampling technique were identified.
B Brambati; E Terzian; G Tognoni
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  11     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  285-93     Citation Subset:  IM    
First Institute of Obstetrics and Gynaecology, University of Milano, Italy.
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MeSH Terms
Birth Weight
Chorionic Villi Sampling / adverse effects,  methods*,  standards
Fetal Death / etiology
Fetal Diseases / diagnosis
Gestational Age
Pregnancy Outcome
Pregnancy Trimester, First

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