| Randomized clinical trial of the effect of preoperative dexamethasone on nausea and vomiting after laparoscopic cholecystectomy. | |
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MedLine Citation:
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PMID: 16400707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Preoperative dexamethasone may reduce disabling symptoms such as pain, nausea and vomiting after laparoscopic cholecystectomy. METHODS: This was a randomized, double-blind, placebo-controlled trial. Between March and December 2004, 101 patients undergoing laparoscopic cholecystectomy were randomized to receive 8 mg dexamethasone (n = 49) or placebo (n = 52) intravenously before surgery. Six patients were excluded from the study. All patients received a standardized anaesthetic, surgical and multimodal analgesic treatment. The primary endpoints were: first, postoperative nausea, vomiting and pain; second, postoperative analgesic and antiemetic requirements. The pain scores (visual analogue and verbal response scales), the episodes of nausea (verbal response scale) and vomiting were recorded at 1, 3, 6 and 24 h, respectively, after the operation. Analgesic and antiemetic requirements were also recorded. RESULTS: No apparent drug side-effects were noted. Seven patients (14 per cent) in the treatment group reported nausea and vomiting compared with 24 (46 per cent) in the control group (P = 0.001). In the group of patients treated with dexamethasone, five (10 per cent) required antiemetics versus 23 (44 per cent) of those receiving placebo (P < 0.001). No difference in postoperative pain scores and analgesic requirements was detected between groups. CONCLUSION: Preoperative dexamethasone reduces postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy, with no side-effects, and may be recommended for routine use. |
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Authors:
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C V Feo; D Sortini; R Ragazzi; M De Palma; A Liboni |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The British journal of surgery Volume: 93 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
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Languages: eng Pagination: 295-9 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Section of General Surgery, Department of Surgery, Anaesthesiology and Radiology, University of Ferrara, Ferrara, Italy. cvfeo@unife.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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therapeutic use Antiemetics / therapeutic use* Cholecystectomy, Laparoscopic / adverse effects* Dexamethasone / therapeutic use* Double-Blind Method Female Gallbladder Diseases / surgery* Humans Length of Stay Male Middle Aged Pain Measurement Pain, Postoperative / prevention & control Patient Satisfaction Postoperative Nausea and Vomiting / prevention & control* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Antiemetics; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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