Document Detail


Randomized clinical trial of the effect of preoperative dexamethasone on nausea and vomiting after laparoscopic cholecystectomy.
MedLine Citation:
PMID:  16400707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Preoperative dexamethasone may reduce disabling symptoms such as pain, nausea and vomiting after laparoscopic cholecystectomy. METHODS: This was a randomized, double-blind, placebo-controlled trial. Between March and December 2004, 101 patients undergoing laparoscopic cholecystectomy were randomized to receive 8 mg dexamethasone (n = 49) or placebo (n = 52) intravenously before surgery. Six patients were excluded from the study. All patients received a standardized anaesthetic, surgical and multimodal analgesic treatment. The primary endpoints were: first, postoperative nausea, vomiting and pain; second, postoperative analgesic and antiemetic requirements. The pain scores (visual analogue and verbal response scales), the episodes of nausea (verbal response scale) and vomiting were recorded at 1, 3, 6 and 24 h, respectively, after the operation. Analgesic and antiemetic requirements were also recorded. RESULTS: No apparent drug side-effects were noted. Seven patients (14 per cent) in the treatment group reported nausea and vomiting compared with 24 (46 per cent) in the control group (P = 0.001). In the group of patients treated with dexamethasone, five (10 per cent) required antiemetics versus 23 (44 per cent) of those receiving placebo (P < 0.001). No difference in postoperative pain scores and analgesic requirements was detected between groups. CONCLUSION: Preoperative dexamethasone reduces postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy, with no side-effects, and may be recommended for routine use.
Authors:
C V Feo; D Sortini; R Ragazzi; M De Palma; A Liboni
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of surgery     Volume:  93     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  295-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Affiliation:
Section of General Surgery, Department of Surgery, Anaesthesiology and Radiology, University of Ferrara, Ferrara, Italy. cvfeo@unife.it
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MeSH Terms
Descriptor/Qualifier:
Analgesics / therapeutic use
Antiemetics / therapeutic use*
Cholecystectomy, Laparoscopic / adverse effects*
Dexamethasone / therapeutic use*
Double-Blind Method
Female
Gallbladder Diseases / surgery*
Humans
Length of Stay
Male
Middle Aged
Pain Measurement
Pain, Postoperative / prevention & control
Patient Satisfaction
Postoperative Nausea and Vomiting / prevention & control*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Analgesics; 0/Antiemetics; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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