Document Detail

Randomized clinical trial on accelerated 7 days per week fractionation in radiotherapy for head and neck cancer. Preliminary report on acute toxicity.
MedLine Citation:
PMID:  8884967     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Toxicity of an accelerated 7 days per week fractionation schedule (arm A) was evaluated and compared with a conventional 5 days per week treatment (arm B) in a randomized trial. MATERIALS AND METHODS: Forty-four patients with squamous cell carcinoma of the head and neck in stage T2-4Nzero-1Mzero were included in the study. Total dose and dose per fraction of 2.0 Gy given once-a-day at 24 h intervals were the same in both arms of the trial. The only difference was the overall treatment time being 5 weeks in arm A and 7 weeks in arm B. RESULTS: Analysis of severe mucosal reactions shows significant difference between arm A and B, with regard to both maximum score and duration of severe mucositis. Confluent mucositis (score > 15 according to the Dische system) lasting longer than 3 weeks developed in 48% of patients in arm A and only in 5% in arm B. In group A seven (30%) late effects (osteo- and soft tissue necrosis) occurred during 7-12 month follow-up with two reactions (10%) in group B being suspected as late effects. There was significant association between acute reactions and late effects in arm A, suggesting that the late effects are consequential. CONCLUSION: The high incidence of severe acute reactions and consequential late effects suggests that the accelerated treatment in arm A (using daily fractions of 2.0 Gy, 7 days per week) gives unacceptable toxicity.
B Maciejewski; K Skladowski; B Pilecki; J M Taylor; R H Withers; L Miszczyk; A Zajusz; R Suwinski
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  40     ISSN:  0167-8140     ISO Abbreviation:  Radiother Oncol     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-28     Completed Date:  1997-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
Centre of Oncology, M. Skłodowska-Curie Memorial Institute, Gliwice, Poland.
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MeSH Terms
Acute Disease
Carcinoma, Squamous Cell / radiotherapy*
Connective Tissue / pathology
Head and Neck Neoplasms / radiotherapy*
Inflammation / etiology
Middle Aged
Mucous Membrane / radiation effects
Osteonecrosis / etiology
Radiation Injuries / etiology*
Radiotherapy / adverse effects
Radiotherapy Dosage
Weight Loss
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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