Document Detail


A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina.
MedLine Citation:
PMID:  23131462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We sought to determine whether 4000 IU/d (vs 2000 IU/d) of vitamin D during pregnancy is safe and improves maternal/neonatal 25-hydroxyvitamin D [25(OH)D] in a dose-dependent manner.
STUDY DESIGN: A total of 257 pregnant women 12-16 weeks' gestation were enrolled. Randomization to 2000 vs 4000 IU/d followed 1-month run-in at 2000 IU/d. Participants were monitored for hypercalciuria, hypercalcemia, and 25(OH)D status.
RESULTS: Maternal 25(OH)D (n = 161) increased from 22.7 ng/mL (SD 9.7) at baseline to 36.2 ng/mL (SD 15) and 37.9 ng/mL (SD 13.5) in the 2000 and 4000 IU groups, respectively. While maternal 25(OH)D change from baseline did not differ between groups, 25(OH)D monthly increase differed between groups (P < .01). No supplementation-related adverse events occurred. Mean cord blood 25(OH)D was 22.1 ± 10.3 ng/mL in 2000 IU and 27.0 ± 13.3 ng/mL in 4000 IU groups (P = .024). After controlling for race and study site, preterm birth and labor were inversely associated with predelivery and mean 25(OH)D, but not baseline 25(OH)D.
CONCLUSION: Maternal supplementation with vitamin D 2000 and 4000 IU/d during pregnancy improved maternal/neonatal vitamin D status. Evidence of risk reduction in infection, preterm labor, and preterm birth was suggestive, requiring additional studies powered for these endpoints.
Authors:
Carol L Wagner; Rebecca McNeil; Stuart A Hamilton; Joyce Winkler; Carolina Rodriguez Cook; Gloria Warner; Betty Bivens; Deborah J Davis; Pamela G Smith; Martha Murphy; Judy R Shary; Bruce W Hollis
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-03
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  208     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-04-18     Revised Date:  2014-10-04    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137.e1-13     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcium / blood,  urine
Community Health Centers
Dietary Supplements*
Dose-Response Relationship, Drug
Double-Blind Method
Female
Fetal Blood / chemistry
Humans
Maternal Welfare*
Pregnancy
Pregnancy Outcome
Questionnaires
South Carolina
Vitamin D / administration & dosage*,  adverse effects,  analogs & derivatives,  blood
Vitamins / administration & dosage*,  adverse effects
Young Adult
Grant Support
ID/Acronym/Agency:
M01 RR001070/RR/NCRR NIH HHS; RR01070/RR/NCRR NIH HHS; UL1 RR029882/RR/NCRR NIH HHS; UL1 RR029882/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Vitamins; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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