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Randomized Study of Autologous Cytokine-induced Killer Cell Immunotherapy in Metastatic Renal Carcinoma.
MedLine Citation:
PMID:  22275504     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The therapeutic benefit of the CIK cells was unknown in the renal cell carcinoma (RCC). This prospectively randomized study was to evaluate the effects of autologous CIK cell immunotherapy in patients with metastatic clear cell RCC.EXPERIMENTAL DESIGN: From June 2005 to June 2008, 148 patients with metastatic clear cell RCC were randomized to autologous CIK cell immunotherapy (Arm 1, n = 74), or interleukin 2 treatment combination with interferon alfa-2a (Arm 2, n = 74). The primary end point was overall survival (OS) and secondary endpoint was progression-free survival (PFS) evaluated by Kaplan-Meier analyses and treatment hazard ratios (HRs) with the Cox proportional hazards model.RESULTS: The 3-year PFS and OS in arm 1 were 18% and 61%, as compared with 12% and 23% in arm 2 (P = 0.031 and < 0.001, respectively). The median PFS and OS in arm 1 were significantly longer than those in arm 2 (PFS, 12 vs. 8 months, P = 0.024; OS, 46 vs. 19 months, P < 0.001). Multivariate analyses indicated that the cycle count of CIK cell immunotherapy as a continuous variable was significantly associated with prolonged PFS (HR = 0.88; 95% CI, 0.84-0.93; P < 0.001) and OS (HR = 0.58; 95% CI, 0.48-0.69; P < 0.001) in arm 1.CONCLUSIONS: The data suggested that CIK cell immunotherapy could improve the prognosis of metastatic clear cell RCC, and increased cycle count of CIK cell treatment could further enhance the beneficial effects.
Authors:
Liang Liu; Weihong Zhang; Xiuying Qi; Hui Li; Jinpu Yu; Sheng Wei; Xishan Hao; Xiubao Ren
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-24
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  -     ISSN:  1078-0432     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China.
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