Document Detail

A randomized placebo-controlled trial of massage therapy on the immune system of preterm infants.
MedLine Citation:
PMID:  23147978     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to investigate the effects of massage therapy (MT) on the immune system of preterm infants. The primary hypothesis was that MT compared with sham therapy (control) will enhance the immune system of stable premature infants by increasing the proportion of their natural killer (NK) cell numbers.
METHODS: A randomized placebo-controlled trial of MT versus sham therapy (control) was conducted among stable premature infants in the NICU. Study intervention was provided 5 days per week until hospital discharge for a maximum of 4 weeks. Immunologic evaluations (absolute NK cells, T and B cells, T cell subsets, and NK cytotoxicity), weight, number of infections, and length of hospital stay were also evaluated.
RESULTS: The study enrolled 120 infants (58 massage; 62 control). At the end of the study, absolute NK cells were not different between the 2 groups; however, NK cytotoxicity was higher in the massage group, particularly among those who received ≥5 consecutive days of study intervention compared with control (13.79 vs 10 lytic units, respectively; P = .04). Infants in the massage group were heavier at end of study and had greater daily weight gain compared with those in the control group; other immunologic parameters, number of infections, and length of stay were not different between the 2 groups.
CONCLUSIONS: In this study, MT administered to stable preterm infants was associated with higher NK cytotoxicity and more daily weight gain. MT may improve the overall outcome of these infants. Larger studies are needed.
Jocelyn Y Ang; Jorge L Lua; Ambika Mathur; Ronald Thomas; Basim I Asmar; Sureyya Savasan; Steven Buck; Michael Long; Seetha Shankaran
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-11-12
Journal Detail:
Title:  Pediatrics     Volume:  130     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-04     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1549-58     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes / immunology
Body Weight
Cross Infection / immunology
Cytotoxicity Tests, Immunologic
Immunocompetence / immunology*
Infant, Newborn
Infant, Premature, Diseases / immunology*,  therapy*
Intensive Care Units, Neonatal
Killer Cells, Natural / immunology*
Length of Stay
Lymphocyte Count*
Lymphocyte Subsets / immunology
T-Lymphocytes / immunology
Grant Support
1 R21 AT001872-01A2/AT/NCCAM NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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