| A randomized placebo-controlled trial of massage therapy on the immune system of preterm infants. | |
| | |
MedLine Citation:
|
PMID: 23147978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The aim of this study was to investigate the effects of massage therapy (MT) on the immune system of preterm infants. The primary hypothesis was that MT compared with sham therapy (control) will enhance the immune system of stable premature infants by increasing the proportion of their natural killer (NK) cell numbers. METHODS: A randomized placebo-controlled trial of MT versus sham therapy (control) was conducted among stable premature infants in the NICU. Study intervention was provided 5 days per week until hospital discharge for a maximum of 4 weeks. Immunologic evaluations (absolute NK cells, T and B cells, T cell subsets, and NK cytotoxicity), weight, number of infections, and length of hospital stay were also evaluated. RESULTS: The study enrolled 120 infants (58 massage; 62 control). At the end of the study, absolute NK cells were not different between the 2 groups; however, NK cytotoxicity was higher in the massage group, particularly among those who received ≥5 consecutive days of study intervention compared with control (13.79 vs 10 lytic units, respectively; P = .04). Infants in the massage group were heavier at end of study and had greater daily weight gain compared with those in the control group; other immunologic parameters, number of infections, and length of stay were not different between the 2 groups. CONCLUSIONS: In this study, MT administered to stable preterm infants was associated with higher NK cytotoxicity and more daily weight gain. MT may improve the overall outcome of these infants. Larger studies are needed. |
| | |
Authors:
|
Jocelyn Y Ang; Jorge L Lua; Ambika Mathur; Ronald Thomas; Basim I Asmar; Sureyya Savasan; Steven Buck; Michael Long; Seetha Shankaran |
Related Documents
:
|
8614338 - Locally acquired brachylaima sp. (digenea: brachylaimidae) intestinal fluke infection i... 15797668 - Reproducibility and reliability of the 13c-acetate breath test to measure gastric empty... 18410468 - The long-term outcome of antenatal hydronephrosis up to 15 millimetres justifies a noni... 6287838 - The effect of bran on bowel function in constipation. 1476148 - Maternal age as a risk factor for wheezing lower respiratory illnesses in the first yea... 14964958 - Tinnitus as a prognostic sign in idiopathic sudden sensorineural hearing loss. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2012-11-12 |
Journal Detail:
|
Title: Pediatrics Volume: 130 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-03 Completed Date: 2013-02-04 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: e1549-58 Citation Subset: AIM; IM |
Affiliation:
|
Division of Infectious Diseases, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201, USA. jang@med.wayne.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
B-Lymphocytes
/
immunology Body Weight Cross Infection / immunology Cytotoxicity Tests, Immunologic Female Humans Immunocompetence / immunology* Infant, Newborn Infant, Premature, Diseases / immunology*, therapy* Intensive Care Units, Neonatal Killer Cells, Natural / immunology* Length of Stay Lymphocyte Count* Lymphocyte Subsets / immunology Male Massage* Michigan T-Lymphocytes / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
1 R21 AT001872-01A2/AT/NCCAM NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expected Body Weight in Adolescents: Comparison Between Weight-for-Stature and BMI Methods.
Next Document: Timing of the Introduction of Complementary Foods in Infancy: A Randomized Controlled Trial.