Document Detail

A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm.
MedLine Citation:
PMID:  20889295     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (AAA) wall stress.
METHODS: A total of 40 patients undergoing elective open AAA repair were randomized to receive either atorvastatin 80 mg (n = 20) or placebo (n = 20) for 4 weeks preoperatively. Finite element analysis was used to determine AAA wall stress distribution. Full thickness aortic samples were obtained at surgery from areas of low and peak wall stress, snap-frozen, and stored at -80°C for subsequent MMP-2, -8, and -9 and TIMP-1 and -2 analyses. Statistical analysis was performed using SPSS 16.0 (SPSS Inc, Chicago, IL).
RESULTS: Both groups were well matched (p > 0.05) regarding age, gender, comorbidities, and duration of hospital stay. There were no statistically significant differences in levels of MMPs and TIMPs between the statin and placebo group and between areas of low and peak AAA wall stress.
CONCLUSION: The short-term use of statins is not associated in reducing levels of MMP 2, 8, and 9 and TIMP-1 and -2 in areas of low and peak wall stress in patients with AAA.
M N A Abdul Rahman; Junaid Alam Khan; Fayyaz Ali Khan Mazari; Katherine Mockford; Peter Thomas McCollum; Ian Clifford Chetter
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  25     ISSN:  1615-5947     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-04-08     Revised Date:  2012-04-23    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
University of Hull, Kingston-upon-Hull, United Kingdom.
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MeSH Terms
Aged, 80 and over
Aorta, Abdominal / drug effects*,  enzymology,  pathology,  surgery
Aortic Aneurysm, Abdominal / drug therapy*,  enzymology,  pathology,  surgery
Chi-Square Distribution
Double-Blind Method
Drug Administration Schedule
Finite Element Analysis
Heptanoic Acids / administration & dosage*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 8 / metabolism
Matrix Metalloproteinase 9 / metabolism
Matrix Metalloproteinases / metabolism*
Middle Aged
Placebo Effect
Preoperative Care
Pyrroles / administration & dosage*
Stress, Mechanical
Surgical Procedures, Elective
Time Factors
Tissue Inhibitor of Metalloproteinase-1 / metabolism
Tissue Inhibitor of Metalloproteinase-2 / metabolism
Tissue Inhibitor of Metalloproteinases / metabolism*
Treatment Outcome
Vascular Surgical Procedures*
Reg. No./Substance:
0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 0/Tissue Inhibitor of Metalloproteinase-1; 0/Tissue Inhibitor of Metalloproteinases; 110862-48-1/atorvastatin; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.-/MMP8 protein, human; EC 3.4.24.-/Matrix Metalloproteinases; EC protein, human; EC Metalloproteinase 2; EC Metalloproteinase 8; EC Metalloproteinase 9
Comment In:
Ann Vasc Surg. 2012 Apr;26(3):444-5   [PMID:  22424452 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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