| A randomized controlled trial of home-based exercise for cancer-related fatigue in women during and after chemotherapy with or without radiation therapy. | |
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MedLine Citation:
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PMID: 20467301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Few studies have evaluated an individualized home-based exercise prescription during and after cancer treatment. OBJECTIVE: The purpose of this study was to evaluate the effectiveness of a home-based exercise training intervention, the Pro-self Fatigue Control Program on the management of cancer-related fatigue. INTERVENTIONS/METHODS: Participants (N = 119) were randomized into 1 of 3 groups: group 1 received the exercise prescription throughout the study; group 2 received their exercise prescription after completing cancer treatment; and group 3 received usual care. Patients completed the Piper Fatigue Scale, General Sleep Disturbance Scale, Center for Epidemiological Studies-Depression Scale, and Worst Pain Intensity Scale. RESULTS: All groups reported mild fatigue levels, sleep disturbance, and mild pain, but not depression. Using multilevel regression analysis, significant linear and quadratic trends were found for change in fatigue and pain (ie, scores increased, then decreased over time). No group differences were found in the changing scores over time. A significant quadratic effect for the trajectory of sleep disturbance was found, but no group differences were detected over time. No significant time or group effects were found for depression. CONCLUSIONS: Our home-based exercise intervention had no effect on fatigue or related symptoms associated with cancer treatment. The optimal timing of exercise remains to be determined. IMPLICATIONS FOR PRACTICE: Clinicians need to be aware that some physical activity is better than none, and there is no harm in exercise as tolerated during cancer treatment. Further analysis is needed to examine the adherence to exercise. More frequent assessments of fatigue, sleep disturbance, depression, and pain may capture the effect of exercise. |
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Authors:
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Marylin J Dodd; Maria H Cho; Christine Miaskowski; Patricia L Painter; Steven M Paul; Bruce A Cooper; John Duda; Joanne Krasnoff; Kayee A Bank |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cancer nursing Volume: 33 ISSN: 1538-9804 ISO Abbreviation: Cancer Nurs Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-08 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7805358 Medline TA: Cancer Nurs Country: United States |
Other Details:
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Languages: eng Pagination: 245-57 Citation Subset: IM; N |
Affiliation:
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School of Nursing, University of California, San Francisco, CA, USA. Marylin.dodd@nursing.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Depression
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etiology Exercise Therapy / organization & administration* Fatigue / diagnosis, etiology, prevention & control* Female Follow-Up Studies Home Care Services / organization & administration* Humans Karnofsky Performance Status Middle Aged Neoplasms* / complications, drug therapy, radiotherapy Nursing Evaluation Research Pain / etiology Patient Compliance Prescriptions Regression Analysis San Francisco Severity of Illness Index Single-Blind Method Sleep Disorders / etiology Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA083316-05/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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