Document Detail

Randomized controlled trial assessing efficacy and safety of glycine powder air polishing in moderate-to-deep periodontal pockets.
MedLine Citation:
PMID:  21861637     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Supragingivally applied glycine powder air polishing (SupraGPAP) has been shown to remove biofilms in shallow periodontal pockets. This study assesses efficacy and safety of subgingivally applied glycine powder air polishing (SubGPAP) in moderate-to-deep periodontal pockets.
METHODS: Patients with chronic periodontitis and intraoral Porphyromonas gingivalis (P. gingivalis) and Tannerella forsythia who completed initial therapy were randomly assigned to receive SubGPAP in periodontal pockets with probing depths of 4 to 9 mm, SupraGPAP in all other shallow periodontal sites, and at mucous membranes followed by removal of calculus using curets (full-mouth GPAP) or scaling and root planing followed by coronal polishing (SRP). Patients rinsed with 0.12% chlorhexidine gluconate after debridement, and twice daily, for 2 weeks.
RESULTS: All 30 patients enrolled completed the baseline, day 10, and day 90 visits. SubGPAP resulted in significantly lower total viable bacterial counts in moderate-to-deep pockets when compared to SRP immediately after debridement and at day 10 (P <0.05). Total P. gingivalis counts in the oral cavity were significantly reduced after full-mouth GPAP compared to SRP at day 90 (P <0.05). Patients' comfort levels were high for both treatments. There were no adverse events related to full-mouth GPAP.
CONCLUSIONS: The results indicate that SubGPAP is more efficacious in removing subgingival biofilm in moderate-to-deep periodontal pockets than SRP. Furthermore, full-mouth GPAP may result in a beneficial shift of the oral microbiota and appears to be well tolerated.
Thomas F Flemmig; Daniyel Arushanov; Diane Daubert; Marilynn Rothen; Gregory Mueller; Brian G Leroux
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-08-23
Journal Detail:
Title:  Journal of periodontology     Volume:  83     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-26     Completed Date:  2012-09-25     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  444-52     Citation Subset:  D; IM    
Department of Periodontics, University of Washington, Seattle, WA 98195-7444, USA.
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MeSH Terms
Anti-Infective Agents, Local / therapeutic use
Bacterial Load
Bacteroidaceae Infections / therapy
Bacteroides / isolation & purification
Chlorhexidine / analogs & derivatives,  therapeutic use
Chronic Periodontitis / microbiology,  therapy
Dental Calculus / therapy
Dental Prophylaxis / methods
Dental Scaling / instrumentation,  methods*
Follow-Up Studies
Glycine / therapeutic use*
Glycine Agents / therapeutic use*
Microbial Viability
Middle Aged
Mouthwashes / therapeutic use
Patient Satisfaction
Periodontal Pocket / microbiology,  therapy*
Porphyromonas gingivalis / isolation & purification
Root Planing / methods
Subgingival Curettage / methods
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Glycine Agents; 0/Mouthwashes; 0/Powders; 55-56-1/Chlorhexidine; 56-40-6/Glycine; MOR84MUD8E/chlorhexidine gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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