Document Detail


Randomized Controlled Study of Plasma Exchange Combined With Molecular Adsorbent Re-Circulating System for the Treatment of Liver Failure Complicated with Hepatic Encephalopathy.
MedLine Citation:
PMID:  22534479     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/Aims: To evaluate the use of plasma exchange (PE) combined with the molecular adsorbent re-circulating system (MARS) for the treatment of liver failure complicated with hepatic encephalopathy. Methodology: A prospective randomized controlled study was conducted to compare the therapeutic effect of MARS treatment (MARS group, n=60) with that of PE combined with MARS treatment (PE+MARS group, n=60) in patients with liver failure complicated with hepatic encephalopathy. Results: The serum total bilirubin and blood ammonia levels were significantly decreased compared with pretreatment levels after 3 days of both the MARS treatment (p=0.0001, p<0.001) and PE+MARS treatment (both p<0.0001) and the Glasgow coma scale score was significantly increased (both p<0.0001). The 30-day mortality rate was 10.0% (6/60) in the MARS group and 11.7% (7/60) in the PE + MARS group. The per capita cost of treatment was significantly lower in the PE + MARS group than in the MARS group (p=0.0003). Conclusions: Both MARS and PE + MARS therapy can safely and effectively be used to treat liver failure complicated with hepatic encephalopathy, but PE + MARS therapy reduces serum total bilirubin level more effectively and is more cost-effective.
Authors:
Yu-Kun Huang; De-Ming Tan; Yu-Tao Xie; Xue-Gong Fan; Yan Huang; Zheng-Bo Liu; Sha-Ling Li
Related Documents :
8852489 - Intravenous ferric saccharate as an iron supplement in dialysis patients.
9663889 - Decrease in staphylococcus aureus exit-site infections and peritonitis in capd patients...
17558069 - Effect of oral glutamine administration on oxidative stress, morbidity and mortality in...
11193939 - Laparoscopic cholecystectomy in a patient on continuous ambulatory peritoneal dialysis.
15185769 - Comparing the incomparable: hemodialysis versus peritoneal dialysis in observational st...
22366389 - The impact of glucocorticoids for cirrhosis patients performed major liver resection: a...
12149529 - Effects of fluticasone propionate in copd patients with bronchial hyperresponsiveness.
17274039 - Cabergoline compared to levodopa in the treatment of patients with severe restless legs...
9619379 - Self-expanding metal oesophageal endoprostheses: which is best?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-25
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  59     ISSN:  0172-6390     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prognostic value of expression of Kit67, p53, TopoIIa and GSTP1 for curatively resected advanced gas...
Next Document:  Full-thickness Cholecystectomy with Limited Lymphadenectomy for Gallbladder Cancer.