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A Randomized Controlled Intervention with Fish Oil versus Sunflower Oil from 9 to 18 Months of Age - Exploring Changes in Growth and Skinfold Thicknesses.
MedLine Citation:
PMID:  21691253     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) from fish oil (FO) have in rodents been shown to reduce adipogenesis. Evidence of an effect on adipose tissue mass in humans is limited and no studies have specifically aimed to elucidate this in infancy. To explore if n-3 LCPUFA-intake affects adipose tissue growth, we randomly allocated 154 healthy infants to daily supplementation with FO or sunflower oil (SO) from 9 to 18 months of age, and measured z-score-changes in various anthropometric assessments of body size and skinfold thicknesses and plasma adipokine concentrations. Among the 133 completing infants erythrocyte n-3 PUFA increased more in those receiving FO than in infants receiving SO (12.2±0.7 (mean±standard error (se)) vs. 2.0±0.4 fatty acid percentage (FA%), P<0.001) with a concomitant larger decrease in n-6 PUFA (-8.9±0.7 vs. -0.9±0.6 FA%, P<0.001). We found no association between FO-consumption relative to SO-consumption and any of the anthropometric measures related to the size of the fat mass, but infants in the FO-group had a lower skinfold-ratio (triceps/subscapular) at 18 months than those in SO-group (P=0.02). Our findings do not support the hypothesis that dietary n-3 LCPUFA is important for infant fat mass, but future studies testing this specifically are warranted. ABBREVIATIONS::
Authors:
Anders D Andersen; Kim F Michaelsen; Lars I Hellgren; Ellen Trolle; Lotte Lauritzen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-17
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Human Nutrition [A.D.A, K.F.M, L.L], University of Copenhagen, Frederiksberg C, DK-1958, Denmark; Department of Systems Biology [L.I.H], Technical University of Denmark, Lyngby, DK-2800, Denmark; National Food Institute [E.T], Technical University of Denmark, Søborg, DK-2860, Denmark.
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